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  4. Recombinant Human Centrobin (CNTROB), partial

Recombinant Human Centrobin (CNTROB), partial

  • 中文名稱：
    Recombinant Human Centrobin(CNTROB) ,partial
  • 貨號：
    CSB-YP822679HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Centrobin(CNTROB) ,partial
  • 貨號：
    CSB-EP822679HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Centrobin(CNTROB) ,partial
  • 貨號：
    CSB-EP822679HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Centrobin(CNTROB) ,partial
  • 貨號：
    CSB-BP822679HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Centrobin(CNTROB) ,partial
  • 貨號：
    CSB-MP822679HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CNTROB
  • Uniprot No.：
  • 別名：
    9830165K03Rik; Centrobin; centrobin; centrosomal BRCA2 interacting protein; Centrosomal BRCA2 interacting protein; Centrosomal BRCA2-interacting protein; CNTRB_HUMAN; Cntrob; LIP8; LYST interacting protein 8; LYST-interacting protein 8; LYST-interacting protein LIP8; PP1221; RGD1307488; RP23 26L6.9
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
  • 基因功能參考文獻：
    1. cytoplasmic centrobin has roles in noncentrosomal microtubule formation in specific cell types and during the cell cycle PMID: 26083938
    2. it is proposed that Centrobin might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix PMID: 23442802
    3. NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin. PMID: 23291182
    4. Our results indicate that genetic polymorphisms of centrobin and Nek2 are related to breast cancer susceptibility in Chinese Han women. PMID: 23001753
    5. Centrobin facilitates the elongation and stability of centrioles via its interaction with tubulins. PMID: 21576394
    6. Data propose that centrobin functions as a microtubule stabilizing factor and PLK1 enhances centrobin activity for proper spindle formation during mitosis. PMID: 20511645
    7. a requirement of Centrobin in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes. PMID: 20190801
    8. Inhibition of p38 activity or downregulation of p38 expression could overcome the cell-cycle arrest caused by centrobin depletion. PMID: 20085806
    9. Centrobin is a centriole-associated protein that asymmetrically localizes to the daughter centriole. PMID: 16275750
    10. Results report that NIP2, previously identified as centrobin, is a novel substrate of Nek2, and that NIP2 has a role in stabilizing the microtubule structure. PMID: 17535851

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.
  • 組織特異性：
    Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 29616

    OMIM: 611425

    KEGG: hsa:116840

    STRING: 9606.ENSP00000369614

    UniGene: Hs.348012



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