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  4. CNTROB Antibody

CNTROB Antibody

  • 中文名稱：
    CNTROB兔多克隆抗體
  • 貨號：
    CSB-PA001554
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HuvEc cells using Centrobin Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CNTROB
  • 別名：
    9830165K03Rik antibody; Centrobin antibody; centrobin; centrosomal BRCA2 interacting protein antibody; Centrosomal BRCA2 interacting protein antibody; Centrosomal BRCA2-interacting protein antibody; CNTRB_HUMAN antibody; Cntrob antibody; LIP8 antibody; LYST interacting protein 8 antibody; LYST-interacting protein 8 antibody; LYST-interacting protein LIP8 antibody; PP1221 antibody; RGD1307488 antibody; RP23 26L6.9 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Centrobin.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
  • 基因功能參考文獻：
    1. cytoplasmic centrobin has roles in noncentrosomal microtubule formation in specific cell types and during the cell cycle PMID: 26083938
    2. it is proposed that Centrobin might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix PMID: 23442802
    3. NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin. PMID: 23291182
    4. Our results indicate that genetic polymorphisms of centrobin and Nek2 are related to breast cancer susceptibility in Chinese Han women. PMID: 23001753
    5. Centrobin facilitates the elongation and stability of centrioles via its interaction with tubulins. PMID: 21576394
    6. Data propose that centrobin functions as a microtubule stabilizing factor and PLK1 enhances centrobin activity for proper spindle formation during mitosis. PMID: 20511645
    7. a requirement of Centrobin in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes. PMID: 20190801
    8. Inhibition of p38 activity or downregulation of p38 expression could overcome the cell-cycle arrest caused by centrobin depletion. PMID: 20085806
    9. Centrobin is a centriole-associated protein that asymmetrically localizes to the daughter centriole. PMID: 16275750
    10. Results report that NIP2, previously identified as centrobin, is a novel substrate of Nek2, and that NIP2 has a role in stabilizing the microtubule structure. PMID: 17535851

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.
  • 組織特異性：
    Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 29616

    OMIM: 611425

    KEGG: hsa:116840

    STRING: 9606.ENSP00000369614

    UniGene: Hs.348012



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