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CNTROB Antibody

  • 中文名稱:
    CNTROB兔多克隆抗體
  • 貨號(hào):
    CSB-PA090803
  • 規(guī)格:
    ¥1100
  • 圖片:
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: CSB-PA090803(CNTROB Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    CNTROB
  • 別名:
    9830165K03Rik antibody; Centrobin antibody; centrobin; centrosomal BRCA2 interacting protein antibody; Centrosomal BRCA2 interacting protein antibody; Centrosomal BRCA2-interacting protein antibody; CNTRB_HUMAN antibody; Cntrob antibody; LIP8 antibody; LYST interacting protein 8 antibody; LYST-interacting protein 8 antibody; LYST-interacting protein LIP8 antibody; PP1221 antibody; RGD1307488 antibody; RP23 26L6.9 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human CNTROB
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
  • 基因功能參考文獻(xiàn):
    1. cytoplasmic centrobin has roles in noncentrosomal microtubule formation in specific cell types and during the cell cycle PMID: 26083938
    2. it is proposed that Centrobin might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix PMID: 23442802
    3. NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin. PMID: 23291182
    4. Our results indicate that genetic polymorphisms of centrobin and Nek2 are related to breast cancer susceptibility in Chinese Han women. PMID: 23001753
    5. Centrobin facilitates the elongation and stability of centrioles via its interaction with tubulins. PMID: 21576394
    6. Data propose that centrobin functions as a microtubule stabilizing factor and PLK1 enhances centrobin activity for proper spindle formation during mitosis. PMID: 20511645
    7. a requirement of Centrobin in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes. PMID: 20190801
    8. Inhibition of p38 activity or downregulation of p38 expression could overcome the cell-cycle arrest caused by centrobin depletion. PMID: 20085806
    9. Centrobin is a centriole-associated protein that asymmetrically localizes to the daughter centriole. PMID: 16275750
    10. Results report that NIP2, previously identified as centrobin, is a novel substrate of Nek2, and that NIP2 has a role in stabilizing the microtubule structure. PMID: 17535851

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  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.
  • 組織特異性:
    Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 29616

    OMIM: 611425

    KEGG: hsa:116840

    STRING: 9606.ENSP00000369614

    UniGene: Hs.348012



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