Recombinant Human Cell adhesion molecule-related/down-regulated by oncogenes (CDON), partial

中文名稱(chēng)：

Recombinant Human Cell adhesion molecule-related/down-regulated by oncogenes(CDON) ,partial
貨號(hào)：

CSB-YP679696HU
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

Recombinant Human Cell adhesion molecule-related/down-regulated by oncogenes(CDON) ,partial
貨號(hào)：

CSB-EP679696HU
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

Recombinant Human Cell adhesion molecule-related/down-regulated by oncogenes(CDON) ,partial
貨號(hào)：

CSB-EP679696HU-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

Recombinant Human Cell adhesion molecule-related/down-regulated by oncogenes(CDON) ,partial
貨號(hào)：

CSB-BP679696HU
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

Recombinant Human Cell adhesion molecule-related/down-regulated by oncogenes(CDON) ,partial
貨號(hào)：

CSB-MP679696HU
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

CDON
Uniprot No.：

Q4KMG0
別名：

CDO; Cdon; CDON_HUMAN; Cell adhesion molecule-related/down-regulated by oncogenes
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
基因功能參考文獻(xiàn)：
1. We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis PMID: 26529631
2. CDO is required for proliferation and survival of lung cancer cells via Hh signaling. PMID: 25369201
3. These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs. PMID: 25313246
4. Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer. PMID: 24740842
5. Mutations in the CDON cause holoprosencephaly. (Review) PMID: 22326621
6. We found that CDON is overexpressed in prostate cancer PMID: 21849809
7. CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. PMID: 21802063
8. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
9. CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID: 12720294
10. CDO and BOC forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact. PMID: 12634428
11. Targeted inactivation of Cdon in the mouse results in mild holoprosencephaly, suggesting a link to signaling pathways that control midline development such as the Sonic hedgehog pathway. PMID: 12620190
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相關(guān)疾病：

Holoprosencephaly 11 (HPE11)
亞細(xì)胞定位：

Cell membrane; Single-pass membrane protein.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 17104

OMIM: 608707

KEGG: hsa:50937

STRING: 9606.ENSP00000263577

UniGene: Hs.38034