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CDON Antibody

  • 中文名稱:
    CDON兔多克隆抗體
  • 貨號:
    CSB-PA005100GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CDO antibody; Cdon antibody; CDON_HUMAN antibody; Cell adhesion molecule-related/down-regulated by oncogenes antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CDON
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
  • 基因功能參考文獻:
    1. We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis PMID: 26529631
    2. CDO is required for proliferation and survival of lung cancer cells via Hh signaling. PMID: 25369201
    3. These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs. PMID: 25313246
    4. Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer. PMID: 24740842
    5. Mutations in the CDON cause holoprosencephaly. (Review) PMID: 22326621
    6. We found that CDON is overexpressed in prostate cancer PMID: 21849809
    7. CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. PMID: 21802063
    8. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
    9. CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID: 12720294
    10. CDO and BOC forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact. PMID: 12634428
    11. Targeted inactivation of Cdon in the mouse results in mild holoprosencephaly, suggesting a link to signaling pathways that control midline development such as the Sonic hedgehog pathway. PMID: 12620190

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  • 相關疾病:
    Holoprosencephaly 11 (HPE11)
  • 亞細胞定位:
    Cell membrane; Single-pass membrane protein.
  • 數據庫鏈接:

    HGNC: 17104

    OMIM: 608707

    KEGG: hsa:50937

    STRING: 9606.ENSP00000263577

    UniGene: Hs.38034



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