在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human CCR4-NOT transcription complex subunit 7 (CNOT7)

  • 中文名稱:
    Recombinant Human CCR4-NOT transcription complex subunit 7(CNOT7)
  • 貨號:
    CSB-YP883446HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human CCR4-NOT transcription complex subunit 7(CNOT7)
  • 貨號:
    CSB-EP883446HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human CCR4-NOT transcription complex subunit 7(CNOT7)
  • 貨號:
    CSB-BP883446HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human CCR4-NOT transcription complex subunit 7(CNOT7)
  • 貨號:
    CSB-MP883446HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    CNOT7
  • Uniprot No.:
  • 別名:
    BTG1 binding factor 1; BTG1-binding factor 1; CAF 1; CAF-1; CAF1; Carbon catabolite repressor protein (CCR4) associative factor 1; CCR4 associated factor 1; CCR4 NOT transcription complex subunit 7; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 7; CNOT 7; Cnot7; CNOT7_HUMAN; hCAF 1; hCAF1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-285
  • 氨基酸序列
    MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG IQFKKHEEEG IETQYFAELL MTSGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGMAFFK MREMFFEDHI DDAKYCGHLY GLGSGSSYVQ NGTGNAYEEE ANKQS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
  • 基因功能參考文獻:
    1. Findings suggest a preferential involvement of CNOT7 variant 2 (CNOT7v2) in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover PMID: 28591869
    2. MEX3C associates with the cytoplasmic deadenylation complexes and ubiquitinates CNOT7. PMID: 26471122
    3. CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by TTP in HPMEC. PMID: 25038453
    4. CNOT7 is an antimicrobial protein and a regulator of the innate immune response. PMID: 23386060
    5. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PMID: 23236473
    6. CNOT7 is not the target tumor suppressor gene in the 8p22-23.1 colorectal cancer suppressor region. PMID: 12845644
    7. CAF1 is a new regulator of PRMT1-dependent arginine methylation. PMID: 17264152
    8. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT7 binds strongly with CNOT6. PMID: 19558367
    9. Data show that efficient cell proliferation requires both CNOT7 and CNOT8, although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins. PMID: 19605561

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, P-body.
  • 蛋白家族:
    CAF1 family
  • 數據庫鏈接:

    HGNC: 14101

    OMIM: 604913

    KEGG: hsa:29883

    STRING: 9606.ENSP00000355279

    UniGene: Hs.587465



主站蜘蛛池模板: 亚洲精品无码成人av电影网| 国产揉捏爆乳巨胸挤奶视频| 孕妇怀孕高潮潮喷视频孕妇| 国产桃色无码视频在线观看 | 亚洲另类无码一区二区三区| 亚洲成av人在线视| 国产精品久久自在自线青柠| 午夜内射中出视频| 国产精品无码一区二区在线观一| 亚洲欧洲日产国码无码av一| 亚洲性夜夜天天天| 热の综合热の国产热の潮在线| 亚洲综合色无码| 久久五月精品中文字幕| 秋霞鲁丝片av无码| 欧美成人午夜性视频| 午夜不卡无码中文字幕影院| 四川少妇大战4黑人| 久久国产avjust麻豆| 52熟女露脸国语对白视频| 久久99精品久久久久久久不卡| av片在线观看| 色翁荡熄又大又硬又粗又视频图片| 久久人妻无码中文字幕第一| 精品无码一区在线观看| 国产草草影院ccyycom| 99久久国产露脸国语对白| 天堂在线资源中文在线8| 久久人人97超碰国产精品| 国产成人片无码视频在线观看| 精品国产乱码久久久人妻| 午夜精品久久久久久久四虎| 国产亚洲精品久久77777| 肥老熟妇伦子伦456视频| 久久国产成人免费网站| 最新在线精品国产福利| 中文字幕在线播放| 中文字幕无码中文字幕有码| 四虎影视无码永久免费| 99久久精品视香蕉蕉| 国产成人无码免费看片软件|