在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CNOT7 Antibody

CNOT7 Antibody

  • 中文名稱：
    CNOT7兔多克隆抗體
  • 貨號：
    CSB-PA001734
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HuvEc cells using CNOT7 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CNOT7
  • 別名：
    BTG1 binding factor 1 antibody; BTG1-binding factor 1 antibody; CAF 1 antibody; CAF-1 antibody; CAF1 antibody; Carbon catabolite repressor protein (CCR4) associative factor 1 antibody; CCR4 associated factor 1 antibody; CCR4 NOT transcription complex subunit 7 antibody; CCR4-associated factor 1 antibody; CCR4-NOT transcription complex subunit 7 antibody; CNOT 7 antibody; Cnot7 antibody; CNOT7_HUMAN antibody; hCAF 1 antibody; hCAF1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human CNOT7.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
  • 基因功能參考文獻：
    1. Findings suggest a preferential involvement of CNOT7 variant 2 (CNOT7v2) in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover PMID: 28591869
    2. MEX3C associates with the cytoplasmic deadenylation complexes and ubiquitinates CNOT7. PMID: 26471122
    3. CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by TTP in HPMEC. PMID: 25038453
    4. CNOT7 is an antimicrobial protein and a regulator of the innate immune response. PMID: 23386060
    5. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PMID: 23236473
    6. CNOT7 is not the target tumor suppressor gene in the 8p22-23.1 colorectal cancer suppressor region. PMID: 12845644
    7. CAF1 is a new regulator of PRMT1-dependent arginine methylation. PMID: 17264152
    8. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT7 binds strongly with CNOT6. PMID: 19558367
    9. Data show that efficient cell proliferation requires both CNOT7 and CNOT8, although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins. PMID: 19605561

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, P-body.
  • 蛋白家族：
    CAF1 family
  • 數據庫鏈接：

    HGNC: 14101

    OMIM: 604913

    KEGG: hsa:29883

    STRING: 9606.ENSP00000355279

    UniGene: Hs.587465



主站蜘蛛池模板： www国产亚洲精品久久| 无码人妻丝袜视频在线播免费| 亚洲精品国产成人无码区a片| 亚洲第一福利网站在线观看 | 日本二区三区欧美亚洲国产| 丰满亚洲大尺度无码无码专线| 中文字幕高清免费日韩视频在线| 国产无套内射久久久国产| 日本丰满熟妇videossex一| 亚洲国产成人精品无码区在线秒播| 日本少妇xxx做受| 伊人狼人大焦香久久网| 人与嘼av免费| 欧美牲交a欧美牲交aⅴ免费真| 色妞色视频一区二区三区四区| 欧洲精品欧美精品| 卡1卡2卡3精品接入口| 国产成人精品高清在线观看93| 亚洲精品一区久久久久久 | 一卡二卡三卡视频| 暖暖 免费 高清 日本 在线| 婷婷五月开心亚洲综合在线| 日韩精品一卡2卡3卡4卡新区视频| 成人毛片100免费观看| 成人影片一区免费观看| 全部孕妇毛片| 玩弄丰满奶水的女邻居| 日韩视频 中文字幕 视频一区| 300部国产真实乱| 西西人体www大胆高清| 国内精品久久久久久久影视| 国产美女视频国产视视频| 国内嫩模私拍精品视频| 国产精品成人av在线观看春天| 性欧美牲交在线视频| 国产欧美日韩亚洲精品专区| 国产精品一区二区高清在线| 大桥久未无码吹潮在线观看| 国产无遮挡裸体免费视频| 少女高清影视在线观看动漫| 丝袜美腿亚洲一区二区|