在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CNOT7 Antibody

CNOT7 Antibody

  • 中文名稱：
    CNOT7兔多克隆抗體
  • 貨號：
    CSB-PA446150
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HUVEC cells and HeLa cells, using CNOT7 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CNOT7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CNOT7
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from N-terminal of Human CNOT7.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
  • 基因功能參考文獻：
    1. Findings suggest a preferential involvement of CNOT7 variant 2 (CNOT7v2) in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover PMID: 28591869
    2. MEX3C associates with the cytoplasmic deadenylation complexes and ubiquitinates CNOT7. PMID: 26471122
    3. CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by TTP in HPMEC. PMID: 25038453
    4. CNOT7 is an antimicrobial protein and a regulator of the innate immune response. PMID: 23386060
    5. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PMID: 23236473
    6. CNOT7 is not the target tumor suppressor gene in the 8p22-23.1 colorectal cancer suppressor region. PMID: 12845644
    7. CAF1 is a new regulator of PRMT1-dependent arginine methylation. PMID: 17264152
    8. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT7 binds strongly with CNOT6. PMID: 19558367
    9. Data show that efficient cell proliferation requires both CNOT7 and CNOT8, although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins. PMID: 19605561

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, P-body.
  • 蛋白家族：
    CAF1 family
  • 數據庫鏈接：

    HGNC: 14101

    OMIM: 604913

    KEGG: hsa:29883

    STRING: 9606.ENSP00000355279

    UniGene: Hs.587465



主站蜘蛛池模板： 2020年最新国产精品正在播放 | 日韩av无码免费播放| 伊伊综合在线视频无码| 欧美成人秋霞久久aa片| 后进式无遮挡啪啪摇乳动态图| 色欲av久久综合人妻无码| 精品一区二区三区在线播放视频 | 国产精品成人精品久久久| 亚洲欧美日韩国产成人精品影院| 成年片色大黄全免费软件到| 99精品丰满人妻无码a片| 亚洲 制服 丝袜 无码 在线| 欧美三级午夜理伦三级| 精品久久久久久无码中文野结衣 | 亚洲精品无码久久久久av麻豆| 熟妇高潮一区二区三区| 午夜精品一区二区三区的区别| 亚洲中文字幕无码mv| 日本视频免费高清一本18| 丰满少妇做爰视频爽爽和| 亚洲第一成人网站| 色综合久久久久无码专区| 国产精品_国产精品_k频道| 97熟女毛毛多熟妇人妻aⅴ| а√在线中文网新版地址在线 | 色噜噜狠狠色综合成人网| 国产av老师丝袜美腿丝袜| 色夜码无码av网站| 精品人妻一区二区三区浪潮在线| 久久人人爽人人爽人人片dvd| 国产最新av在线播放不卡| 亚洲精品v日韩精品| 欧美黑人添添高潮a片www| 西西人体大胆瓣开下部毛茸茸| 国产亚洲精品一区在线播放| 国产精品久久久久久亚洲色| 国产精品沙发午睡系列990531| 国产影片av级毛片特别刺激| 邪恶肉肉全彩色无遮盖| 免费看又黄又无码的网站| 国产成人精品2021|