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  4. Recombinant Human Adenylate cyclase type 10 (ADCY10), partial

Recombinant Human Adenylate cyclase type 10 (ADCY10), partial

  • 中文名稱：
    Recombinant Human Adenylate cyclase type 10(ADCY10) ,partial
  • 貨號：
    CSB-YP839393HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Adenylate cyclase type 10(ADCY10) ,partial
  • 貨號：
    CSB-EP839393HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Adenylate cyclase type 10(ADCY10) ,partial
  • 貨號：
    CSB-EP839393HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Adenylate cyclase type 10(ADCY10) ,partial
  • 貨號：
    CSB-BP839393HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Adenylate cyclase type 10(ADCY10) ,partial
  • 貨號：
    CSB-MP839393HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ADCY10; SAC; Adenylate cyclase type 10; EC 4.6.1.1; AH-related protein; Adenylate cyclase homolog; Germ cell soluble adenylyl cyclase; hsAC; sAC; Testicular soluble adenylyl cyclase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation.
  • 基因功能參考文獻：
    1. results thus provide 1) novel insights into the communication between allosteric regulatory and active sites, 2) a novel mechanism for sAC inhibition, and 3) pharmacological compounds targeting this allosteric site and utilizing this mode of inhibition. PMID: 26961873
    2. The data support an important role for prostaglandin activation of sAC and PKA in H2O2-induced barrier disruption. PMID: 26857816
    3. Evaluation of soluble adenylyl cyclase expression using R21 antibody is a useful diagnostic adjunct in the evaluation of margins of LM during slow Mohs surgery. PMID: 24698940
    4. shows that in fibroblast cultures inhibition by KH7 of production in the mitochondrial matrix by soluble adenylyl cyclase PMID: 25409931
    5. Crystal structures of human ADCY10 catalytic domains in complex with nucleotides. PMID: 25040695
    6. Soluble adenylyl cyclase plays a role in the regulation of basal cCMP and cUMP. PMID: 24792377
    7. sAC is a regulator of gene expression involved in aldosterone signaling and an important regulator of endothelial stiffness. PMID: 24420537
    8. sAC is necessary for normal glucose-stimulated insulin secretion in vitro and in vivo. PMID: 24100033
    9. a haem-binding domain within the C-terminus of the human soluble adenylate cyclase PMID: 22775536
    10. Significant overexpression of soluble type 10 adenylyl cyclase (sAC), an alternative source of cAMP, was found in human prostate carcinoma. PMID: 23255611
    11. Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. PMID: 21994938
    12. sAC may play a role in the pathogenesis of certain hyperproliferative skin disorders via modulation of gene expression PMID: 20130594
    13. Soluble adenylyl cyclase is localized to motile airway cilia and it contributes to the regulation of human airway ciliary beat frequency. PMID: 17591988
    14. These results show that bicarbonate-controlled sAC stimulation must be taken into account in cell physiology and that basal CFTR expression depends on an ionic parameter. PMID: 18209474
    15. a modest association between an ADCY10 polymorphism and the spinal areal BMD in premenopausal white women. PMID: 19093065

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  • 相關疾病：
    Hypercalciuria absorptive 2 (HCA2)
  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Nucleus. Cell projection, cilium. Cytoplasm. Mitochondrion.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性：
    Detected in airway epithelial cells and testis (at protein level). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial c
  • 數據庫鏈接：

    HGNC: 21285

    OMIM: 143870

    KEGG: hsa:55811

    STRING: 9606.ENSP00000356825

    UniGene: Hs.320892



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