在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial

In Stock
  • 中文名稱:
    Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial
  • 品名簡稱:
    Recombinant Human CHRNB1 protein, partial
  • 貨號:
    CSB-EP005395HU
  • 說明書:
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    32
  • 表達區域:
    24-244aa
  • 氨基酸序列
    SEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻:
    1. Study traced the cause of congenital myasthenia syndrome in unrelated patients with dominant missense mutations in the M2 domain of AChR. A valine residue is replaced by a smaller alanine either in the epsilon subunit or an equivalent position in the beta one. Also, each valine in the valine ring was found to contribute to channel kinetics equally, and the valine ring has bee optimized during evolution to govern channe... PMID: 27375219
    2. This study reports on the presence of the CHRNB1 at the cellular level in human skeletal muscle and placenta and that mRNA expression mirrors that of protein within cell types. PMID: 28153524
    3. These findings identify novel Golgi retention signals in the beta and delta subunit loops that regulate surface trafficking of assembled AChR and may help prevent surface expression of unassembled subunits. PMID: 24240098
    4. Single nucleotide polymorphisms , rs55633891 (alpha9, C>T) and rs17856697 (beta1, A>G), did not exhibit a significant trend to be associated with cervical lesions. PMID: 22406075
    5. the beta1 subunit showed significantly increased expression in lung tumors as compared to non-tumor bronchial tissue PMID: 17015027
    6. Extracellular beta1-beta2 and cysteine-loops bridge the pre-M1 transmembrane domain and M2-M3 linker to transduce agonist binding into channel gating. PMID: 19279256

    顯示更多

    收起更多

  • 相關疾病:
    Myasthenic syndrome, congenital, 2A, slow-channel (CMS2A); Myasthenic syndrome, congenital, 2C, associated with acetylcholine receptor deficiency (CMS2C)
  • 亞細胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Beta-1/CHRNB1 sub-subfamily
  • 數據庫鏈接:

    HGNC: 1961

    OMIM: 100710

    KEGG: hsa:1140

    STRING: 9606.ENSP00000304290

    UniGene: Hs.330386



主站蜘蛛池模板: 国产丝袜肉丝视频在线| 黑人巨大精品欧美| 一本加勒比hezyo无码资源网| 亚洲欧美日韩国产综合v| 国产在线码观看清码视频| 久久性色av亚洲电影| 色欲色香天天天综合网www | 久久久一本精品99久久精品66| 中文字幕人妻被公上司喝醉| 国产精品人妻在线观看| 免费观看黄网站在线播放| 免费的很黄很污的视频| 日本十八禁黄无遮禁视频免费| 国产亚洲精品久久一区二区| 日韩成人无码影院| 成人午夜国产内射主播| 国产成人高清精品免费| av无码天一区二区一三区| 中国丰满熟妇xxxx性| 五十路熟妇亲子交尾| 不卡av中文字幕手机看| 国产高清不卡一区二区| 狠狠色狠狠色综合日日不卡| 人妻无码一区二区三区tv | 国产午夜精品免费一区二区三区| 中文午夜人妻无码看片| 人妻少妇精品中文字幕av蜜桃| 丝袜老师办公室里做好紧好爽| 日本一区二区三区免费播放视频站| 国产v在线在线观看视频免费| 国产乱人伦偷精品视频| 永久黄网站免费视频性色| 国产百合互慰吃奶互揉视频| 欧美人与动牲猛交a欧美精品 | 亚洲 综合 自拍 精品 在线| 久久亚洲国产成人精品无码区 | 肉色欧美久久久久久久免费看| 国产精品久久久天天影视| 9999国产精品欧美久久久久久| 亚洲人成欧美中文字幕| 午夜成人亚洲理伦片在线观看|