在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial

In Stock
  • 中文名稱:
    Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial
  • 貨號:
    CSB-EP005395HUb1
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    32.5
  • 表達區(qū)域:
    24-244aa
  • 氨基酸序列
    SEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻:
    1. Study traced the cause of congenital myasthenia syndrome in unrelated patients with dominant missense mutations in the M2 domain of AChR. A valine residue is replaced by a smaller alanine either in the epsilon subunit or an equivalent position in the beta one. Also, each valine in the valine ring was found to contribute to channel kinetics equally, and the valine ring has bee optimized during evolution to govern channe... PMID: 27375219
    2. This study reports on the presence of the CHRNB1 at the cellular level in human skeletal muscle and placenta and that mRNA expression mirrors that of protein within cell types. PMID: 28153524
    3. These findings identify novel Golgi retention signals in the beta and delta subunit loops that regulate surface trafficking of assembled AChR and may help prevent surface expression of unassembled subunits. PMID: 24240098
    4. Single nucleotide polymorphisms , rs55633891 (alpha9, C>T) and rs17856697 (beta1, A>G), did not exhibit a significant trend to be associated with cervical lesions. PMID: 22406075
    5. the beta1 subunit showed significantly increased expression in lung tumors as compared to non-tumor bronchial tissue PMID: 17015027
    6. Extracellular beta1-beta2 and cysteine-loops bridge the pre-M1 transmembrane domain and M2-M3 linker to transduce agonist binding into channel gating. PMID: 19279256

    顯示更多

    收起更多

  • 相關疾病:
    Myasthenic syndrome, congenital, 2A, slow-channel (CMS2A); Myasthenic syndrome, congenital, 2C, associated with acetylcholine receptor deficiency (CMS2C)
  • 亞細胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Beta-1/CHRNB1 sub-subfamily
  • 數據庫鏈接:

    HGNC: 1961

    OMIM: 100710

    KEGG: hsa:1140

    STRING: 9606.ENSP00000304290

    UniGene: Hs.330386



主站蜘蛛池模板: 精品国产成人网站一区在线| 强插女教师av在线| 久久精品亚洲成在人线av麻豆| 久久久久久无码日韩欧美| 亚洲午夜成人精品无码| 日本成本人片免费网站| 久久99精品国产麻豆| 亚洲色大成网站www永久麻豆| 免费看国产成年无码av| 久久人搡人人玩人妻精品 | 亚洲乱亚洲乱妇50p| 色翁荡息又大又硬又粗又爽| 办公丝袜av一区二区三区| 国产欧美国日产高清| 国产美女在线精品免费观看网址| 中文在线а天堂中文在线新版 | 欧美日韩色另类综合| 欧美国产综合欧美视频| 亚洲暴爽av人人爽日日碰| 亚洲欧美成人中文日韩电影网站| 少妇人妻真实偷人精品视频 | 九九视频在线观看视频6| 免费两性的视频网站| 国产精品夜夜春夜夜爽久久小说| 国产精品一区二区熟女不卡| 99久久人妻无码精品系列| 18禁黄网站禁片免费观看不卡| 亚洲色中文字幕在线播放| 熟妇高潮精品一区二区三区| 亚洲乱亚洲乱少妇无码99p| av无码人妻一区二区三区牛牛| 国产网曝门亚洲综合在线| 亚洲精品无播放器在线播放| 久久国产成人精品国产成人亚洲 | 国产精品原创av片国产日韩| 色欲av伊人久久大香线蕉影院| 欧美成 人版中文字幕| 久久亚洲日韩精品一区二区三区| 免费三级网站| 国产女人精品视频国产灰线| 又大又粗又爽免费视频a片|