在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human ADP/ATP translocase 4 (SLC25A31), partial

Recombinant Human ADP/ATP translocase 4 (SLC25A31), partial

  • 中文名稱：
    人SLC25A31重組蛋白
  • 貨號：
    CSB-YP861982HU1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC25A31重組蛋白
  • 貨號：
    CSB-EP861982HU1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC25A31重組蛋白
  • 貨號：
    CSB-EP861982HU1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC25A31重組蛋白
  • 貨號：
    CSB-BP861982HU1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC25A31重組蛋白
  • 貨號：
    CSB-MP861982HU1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    SLC25A31; AAC4; ANT4; SFEC; ADP/ATP translocase 4; ADP,ATP carrier protein 4; Adenine nucleotide translocator 4; ANT 4; Solute carrier family 25 member 31; Sperm flagellar energy carrier protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes. Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it.
  • 基因功能參考文獻(xiàn)：
    1. Male mice with disruptions of Slc25a31 are sterile and display an early meiotic arrest phenotype. PMID: 19556438
    2. Data show the specific role of the ANT4 isoform in spermatozoid bioenergetics. PMID: 21827840
    3. data define common and distinct biochemical characteristics of ANT4 in comparison to ANT1, 2 and 3 providing a basis for study of its unique adaptation to germ cells PMID: 21532989
    4. data highlight a cytoprotective activity of ANT4, and provide a novel dichotomy in the ANT isoform sub-family with ANT1 and 3 isoforms functioning as pro-apoptotic while ANT2 and 4 isoforms render cells resistant to death inducing stimuli PMID: 20060930
    5. The co-localization of SFEC and glycolytic enzymes in the fibrous sheath supports a growing literature that the principal piece of the flagellum is capable of generating and regulating ATP independently from mitochondrial oxidation in the mid-piece. PMID: 17137571

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性：
    Expressed in brain, liver, sperm and testis. In testis, expressed at higher level in spermatocytes, while it is expressed at lower level in spermatogonial cells. Expressed in erythrocytes (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25319

    OMIM: 610796

    KEGG: hsa:83447

    STRING: 9606.ENSP00000281154

    UniGene: Hs.149030



主站蜘蛛池模板： 免费精品国产自在| 日本一道一区二区视频| 亚洲va中文字幕无码久久不卡| 国产精品视频二区不卡| 久久久精品波多野结衣| 亚洲高清国产拍精品网络战| 亚洲精品成人福利网站| 国产99久久精品一区二区| 无码人妻精品一区二区| 亚洲国产精品无码久久一线| 免费人成激情视频在线观看| 国产在线永久视频| 国自产拍偷拍精品啪啪一区二区 | 国产福利自产拍| 久久99精品国产麻豆婷婷洗澡| 日韩精品一区二区在线观看| 日本一区二区三区免费更新不卡| 高清国产亚洲欧洲av综合一区| 中文无码精品一区二区三区| 欧洲熟妇色xxxx欧美老妇多毛网站 | 国语高潮无遮挡无码免费看| 中文字幕一区二区三区乱码 | 真实国产精品vr专区| 伊人久久大香线蕉成人| 成人精品视频99在线观看免费| 成人亚洲精品久久久久| 热の综合热の国产热の潮在线| 内射人妻无码色ab麻豆| 337p人体粉嫩胞高清视频| 久久天天躁狠狠躁夜夜av浪潮| 亚洲人成黄网站69影院| 内射国产内射夫妻免费频道| 亚洲中文字幕婷婷在线| 丁香五月激情综合亚洲| 无码乱码av天堂一区二区| 色欲欲www成人网站| 久久和欧洲码一码二码三码| 国产又黄又大又粗视频| 爽爽精品dvd蜜桃成熟时电影院 | 色婷婷久久综合中文久久一本| 天堂在/线资源中文在线8|