在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC25A31 Antibody

  • 中文名稱:
    SLC25A31兔多克隆抗體
  • 貨號(hào):
    CSB-PA076262
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from COLO cells, HUVEC cells and HeLa cells, using SLC25A31 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SLC25A31 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    SLC25A31; AAC4; ANT4; SFEC; ADP/ATP translocase 4; ADP,ATP carrier protein 4; Adenine nucleotide translocator 4; ANT 4; Solute carrier family 25 member 31; Sperm flagellar energy carrier protein
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human SLC25A31.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes. Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it.
  • 基因功能參考文獻(xiàn):
    1. Male mice with disruptions of Slc25a31 are sterile and display an early meiotic arrest phenotype. PMID: 19556438
    2. Data show the specific role of the ANT4 isoform in spermatozoid bioenergetics. PMID: 21827840
    3. data define common and distinct biochemical characteristics of ANT4 in comparison to ANT1, 2 and 3 providing a basis for study of its unique adaptation to germ cells PMID: 21532989
    4. data highlight a cytoprotective activity of ANT4, and provide a novel dichotomy in the ANT isoform sub-family with ANT1 and 3 isoforms functioning as pro-apoptotic while ANT2 and 4 isoforms render cells resistant to death inducing stimuli PMID: 20060930
    5. The co-localization of SFEC and glycolytic enzymes in the fibrous sheath supports a growing literature that the principal piece of the flagellum is capable of generating and regulating ATP independently from mitochondrial oxidation in the mid-piece. PMID: 17137571

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性:
    Expressed in brain, liver, sperm and testis. In testis, expressed at higher level in spermatocytes, while it is expressed at lower level in spermatogonial cells. Expressed in erythrocytes (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 25319

    OMIM: 610796

    KEGG: hsa:83447

    STRING: 9606.ENSP00000281154

    UniGene: Hs.149030



主站蜘蛛池模板: 国产精品无码久久久久久久久久| 国产高清色高清在线观看| 亚洲中久无码永久在线观看同| 亚洲线精品一区二区三区影音先锋| 国产亚洲精品久久久久蜜臀| 日本少妇裸体做爰高潮片| 成在人线av无码免费高潮水老板| 中文字幕在线精品视频入口一区| 色综合伊人丁香五月桃花婷婷| 亚洲人成无码网站久久99热国产| 四虎影视国产精品久久| 欧美综合乱图图区乱图图区| 国产成人一区二区三区app | 精品亚洲卡一卡2卡三卡乱码| 岛国av动作片在线观看 | 日韩国产精品人妻无码久久久| 丝袜高潮流白浆潮喷在线播放| 伊人色合天天久久综合网| 亚洲多毛妓女毛茸茸的| 免费大黄网站| 人妻影音先锋啪啪av资源| 亚洲综合欧美在线一区在线播放 | √最新版天堂资源网在线下载| 中字幕视频在线永久在线观看免费| 香蕉av福利精品导航| 中文字幕乱人伦高清视频| 久久综合久中文字幕青草| 国产口爆吞精在线视频2020版 | 99久热re在线精品视频| 色av专区无码影音先锋| 精品人妻无码一区二区三区性| 亚洲精品一区二区三区婷婷月| 天天躁久久躁日日躁| 成人毛片100免费观看| 天天天欲色欲色www免费| 蜜臀av国产一区二区三区| 好爽好湿好硬好大免费视频| 丰满人妻一区二区三区免费视频| 业余 自由 性别 成熟视频 视频 | 久久久久亚洲精品| 57pao成人国产永久免费视频|