在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC25A31 Antibody

  • 中文名稱:
    SLC25A31兔多克隆抗體
  • 貨號:
    CSB-PA000884
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO205 cells using ANT4 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    SLC25A31; AAC4; ANT4; SFEC; ADP/ATP translocase 4; ADP,ATP carrier protein 4; Adenine nucleotide translocator 4; ANT 4; Solute carrier family 25 member 31; Sperm flagellar energy carrier protein
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human ANT4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes. Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it.
  • 基因功能參考文獻:
    1. Male mice with disruptions of Slc25a31 are sterile and display an early meiotic arrest phenotype. PMID: 19556438
    2. Data show the specific role of the ANT4 isoform in spermatozoid bioenergetics. PMID: 21827840
    3. data define common and distinct biochemical characteristics of ANT4 in comparison to ANT1, 2 and 3 providing a basis for study of its unique adaptation to germ cells PMID: 21532989
    4. data highlight a cytoprotective activity of ANT4, and provide a novel dichotomy in the ANT isoform sub-family with ANT1 and 3 isoforms functioning as pro-apoptotic while ANT2 and 4 isoforms render cells resistant to death inducing stimuli PMID: 20060930
    5. The co-localization of SFEC and glycolytic enzymes in the fibrous sheath supports a growing literature that the principal piece of the flagellum is capable of generating and regulating ATP independently from mitochondrial oxidation in the mid-piece. PMID: 17137571

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性:
    Expressed in brain, liver, sperm and testis. In testis, expressed at higher level in spermatocytes, while it is expressed at lower level in spermatogonial cells. Expressed in erythrocytes (at protein level).
  • 數據庫鏈接:

    HGNC: 25319

    OMIM: 610796

    KEGG: hsa:83447

    STRING: 9606.ENSP00000281154

    UniGene: Hs.149030



主站蜘蛛池模板: 中文有码无码人妻在线| 欧美亚洲日本国产综合在线| 女狠狠噜天天噜日日噜| 国产午夜无码片在线观看| 无码人妻一区二区三区av| 女性高爱潮视频| 含紧一点h边做边走动免费视频| 欧美又粗又长又爽做受| 国产在线观看免费视频软件| 尤物蜜芽国产成人精品区| 99精品人妻少妇一区二区| 亚洲精品国产一区二区贰佰信息网| 人人超碰人摸人爱| 无码ol丝袜高跟秘书在线观看| 九九久久精品国产波多野结衣| 男女18禁啪啪无遮挡| 无码少妇一区二区| 国产成人精品午夜福利在线观看| 亚洲 一区二区 在线| 最近中文av字幕在线中文| 躁躁躁日日躁| 日本xxxx色视频在线观看| 亚洲伊人久久成人综合网| 东京热久久综合久久88| 日韩亚洲欧美中文在线| 一区二区视频传媒有限公司| 亚洲综合激情五月丁香六月| 天美传媒一区二区| 欧美乱妇高清无乱码免费| 看国产黄大片在线观看| 国产高清视频色拍| 中文字幕aⅴ在线视频| 精品一区二区三区无码视频| 日本成熟老妇乱| 国语自产拍在线视频中文| 午夜无码成人免费视频| 亚洲国产av无码精品| 一本久久综合亚洲鲁鲁五月天| 亚洲中文字幕乱码一区| 一本加勒比hezyo无码专区| 久久精品无码中文字幕|