在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human 3-keto-steroid reductase (HSD17B7), partial

Recombinant Human 3-keto-steroid reductase (HSD17B7), partial

  • 中文名稱：
    人HSD17B7重組蛋白
  • 貨號：
    CSB-YP010776HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HSD17B7重組蛋白
  • 貨號：
    CSB-EP010776HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HSD17B7重組蛋白
  • 貨號：
    CSB-EP010776HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HSD17B7重組蛋白
  • 貨號：
    CSB-BP010776HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HSD17B7重組蛋白
  • 貨號：
    CSB-MP010776HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HSD17B7
  • Uniprot No.：
  • 別名：
    HSD17B7; 17HSD7; SDR37C1; UNQ2563/PRO6243; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; Dihydrotestosterone oxidoreductase; Estradiol 17-beta-dehydrogenase 7; Short chain dehydrogenase/reductase family 37C member 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis. Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol. Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase.; Does not have enzymatic activities toward E1 and DHT.
  • 基因功能參考文獻：
    1. Inhibition of 17beta-HSD 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78. PMID: 28645527
    2. Substrate inhibition of 17beta-HSD1 in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 knockdown has been demonstrated. PMID: 28554725
    3. the dual functional 17beta-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of estradiol and dihydrotestosterone. PMID: 25966904
    4. 17beta-HSD1 and 17beta-HSD7 are principal reductive 17beta-hydroxysteroid dehydrogenases and major players in the viability of estrogen-dependent breast cancer cells. PMID: 25257817
    5. The transcriptional activity of the HSD17B7 gene containing the G allele is higher than that of the C allele. This difference in HSD17B7 expression may regulate the risk of peripheral edema as an adverse reaction induced by estramustine phosphate sodium PMID: 19735314
    6. 17betaHSD7 is not the key enzyme responsible for androstenone and testosterone metabolism in porcine liver cells PMID: 23300627
    7. Data show that apicidin significantly lowers HSD17B1 transcript and protein levels in endometrial adenocarcinoma cells, with no significant effect on HSD17B1 transcript stability. PMID: 21086175
    8. estradiol stimulates HSD17B7 transcriptional activity in breast cancer cells through a novel mechanism requiring NF1 and strongly suggest a positive feedback mechanism, increasing estradiol synthesis causing growth of estrogen-dependent breast cancers PMID: 21372145
    9. increased expression of HSD17B7 is associated with breast cancer. PMID: 20215536
    10. HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism PMID: 12829805
    11. Comparison of the promoter region of the human and murine gene. PMID: 15862973
    12. The identified proximal promoter regions of both human and murine HSD17B7 genes contain multiple transcription factor binding sites and show strong similarity to cholesterogenic genes. PMID: 16356630
    13. Results provide unequivocal evidence for a role of 17beta-hydroxysteroid dehydrogenase type-7 in cholesterol biosynthesis. PMID: 16901934
    14. 17beta-hydroxysteroid dehydrogenase type 7(17beta-HSD type 7)was significantly upregulated in ovarian tissue of patients with ovarian endometriosis. PMID: 17454161
    15. 17-beta hydroxysteroid dehydrogenase type 7 (HSD17B7) -shRNA sequences were designed and tested for their effectiveness. PMID: 17498944

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family, ERG27 subfamily
  • 組織特異性：
    Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested.; [Isoform 3]:
  • 數據庫鏈接：

    HGNC: 5215

    OMIM: 606756

    KEGG: hsa:51478

    STRING: 9606.ENSP00000254521

    UniGene: Hs.492925



主站蜘蛛池模板： 中国产xxxxa片在线观看| 国产美女午夜福利视频| 宅男宅女精品国产av天堂| 粗大的内捧猛烈进出看视频| 亚洲全部无码中文字幕| 久久综合九色综合网站| 天天狠天天天天透在线 | 国产成人久久婷婷精品流白浆| 一本加勒比hezyo无码资源网 | 国自产拍偷拍精品啪啪一区二区| 欧美国产日产一区二区| 国产精品尹人在线观看| 波多野结衣潮喷视频无码42 | 中文字幕日韩一区二区三区不卡| 婷婷成人丁香五月综合激情| 亚洲无人区午夜福利码高清完整版 | 免费做爰猛烈吃奶摸视频在线观看| 亚洲中文字幕无码中文字在线| 性色a∨精品高清在线观看| 天天躁日日躁狠狠躁性色av| 国产白嫩护士被弄高潮| 国产午夜毛片v一区二区三区| 亚洲午夜性猛春交xxxx| 国产真实伦在线观看视频| 色偷偷人人澡久久超碰97| 国产作爱激烈叫床视频| 国产无遮挡裸体免费视频在线观看 | 免费观看男女性高视频| 亚洲va韩国va欧美va| 天天爽天天爽夜夜爽毛片 | 成人伊人青草久久综合网| 久久无码人妻一区二区三区| 亚洲国产成人av人片久久| 国产熟妇人妻精品一区二区动漫| 亚洲一区二区三区| 精国产品一区二区三区a片| 亚洲无人区午夜福利码高清完整版 | 超碰97人人射妻| 青青草无码免费一二三区| 国产人妻精品一区二区三首 | 香蕉视频在线精品视频|