在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HSD17B7 Antibody

  • 中文名稱:
    HSD17B7兔多克隆抗體
  • 貨號:
    CSB-PA010776LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA010776LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA010776LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HSD17B7 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HSD17B7
  • 別名:
    HSD17B7; 17HSD7; SDR37C1; UNQ2563/PRO6243; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; Dihydrotestosterone oxidoreductase; Estradiol 17-beta-dehydrogenase 7; Short chain dehydrogenase/reductase family 37C member 1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human 3-keto-steroid reductase protein (128-198AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,HSD17B7 Antibody (CSB-PA010776LA01HU),的標記方式是Non-conjugated。對于HSD17B7 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA010776LB01HU HSD17B7 Antibody, HRP conjugated ELISA
    FITC CSB-PA010776LC01HU HSD17B7 Antibody, FITC conjugated
    Biotin CSB-PA010776LD01HU HSD17B7 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis. Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol. Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase.; Does not have enzymatic activities toward E1 and DHT.
  • 基因功能參考文獻:
    1. Inhibition of 17beta-HSD 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78. PMID: 28645527
    2. Substrate inhibition of 17beta-HSD1 in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 knockdown has been demonstrated. PMID: 28554725
    3. the dual functional 17beta-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of estradiol and dihydrotestosterone. PMID: 25966904
    4. 17beta-HSD1 and 17beta-HSD7 are principal reductive 17beta-hydroxysteroid dehydrogenases and major players in the viability of estrogen-dependent breast cancer cells. PMID: 25257817
    5. The transcriptional activity of the HSD17B7 gene containing the G allele is higher than that of the C allele. This difference in HSD17B7 expression may regulate the risk of peripheral edema as an adverse reaction induced by estramustine phosphate sodium PMID: 19735314
    6. 17betaHSD7 is not the key enzyme responsible for androstenone and testosterone metabolism in porcine liver cells PMID: 23300627
    7. Data show that apicidin significantly lowers HSD17B1 transcript and protein levels in endometrial adenocarcinoma cells, with no significant effect on HSD17B1 transcript stability. PMID: 21086175
    8. estradiol stimulates HSD17B7 transcriptional activity in breast cancer cells through a novel mechanism requiring NF1 and strongly suggest a positive feedback mechanism, increasing estradiol synthesis causing growth of estrogen-dependent breast cancers PMID: 21372145
    9. increased expression of HSD17B7 is associated with breast cancer. PMID: 20215536
    10. HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism PMID: 12829805
    11. Comparison of the promoter region of the human and murine gene. PMID: 15862973
    12. The identified proximal promoter regions of both human and murine HSD17B7 genes contain multiple transcription factor binding sites and show strong similarity to cholesterogenic genes. PMID: 16356630
    13. Results provide unequivocal evidence for a role of 17beta-hydroxysteroid dehydrogenase type-7 in cholesterol biosynthesis. PMID: 16901934
    14. 17beta-hydroxysteroid dehydrogenase type 7(17beta-HSD type 7)was significantly upregulated in ovarian tissue of patients with ovarian endometriosis. PMID: 17454161
    15. 17-beta hydroxysteroid dehydrogenase type 7 (HSD17B7) -shRNA sequences were designed and tested for their effectiveness. PMID: 17498944

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族:
    Short-chain dehydrogenases/reductases (SDR) family, ERG27 subfamily
  • 組織特異性:
    Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested.; [Isoform 3]:
  • 數據庫鏈接:

    HGNC: 5215

    OMIM: 606756

    KEGG: hsa:51478

    STRING: 9606.ENSP00000254521

    UniGene: Hs.492925



主站蜘蛛池模板: 欧产日产国产精品| 777精品出轨人妻国产| 国产α片免费观看在线人| 久久99亚洲精品久久久久| 两女女百合互慰av赤裸无遮挡| 99久热在线精品视频观看| 少妇高潮无套内谢| 99视频国产精品免费观看| 婷婷伊人五月尤物| 中文字幕乱码人妻综合二区三区| 人妻少妇被粗大爽.9797pw| 亚洲熟妇av一区二区三区宅男| 国产精品久久久久久影视不卡| 成年女性特黄午夜视频免费看| 高潮喷水无码av亚洲| 亚洲色无码专区一区| 夜夜高潮夜夜爽夜夜爱爱| 国产熟睡乱子伦视频| 欧美老妇bbbwwbbbww| 无码啪啪熟妇人妻区 | 人妻换人妻仑乱| 国产做a爱免费视频在线观看| 三级网站视频在在线播放| 色婷婷美国农夫综合激情亚洲| 亚洲精品一区二区三区四区五区| 亚洲处破女av日韩精品| 日本wv一本一道久久香蕉| 精产国品一二三产品蜜桃| 中文字幕人成无码人妻| 亚洲日韩性欧美中文字幕| 亚洲综合久久一本伊一区| 成人午夜福利视频镇东影视| 无码熟妇人妻av在线影片最多| 4hu四虎永久在线影院| 无码国产精品久久一区免费| 无码一区二区三区av免费| 卡1卡2卡3精品接入口| 精品久久久久香蕉网| 亚洲欧美日韩精品色xxx| 国产成人mv视频在线观看| 丰满人妻被中出中文字幕|