在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Cat Macrophage colony-stimulating factor 1 receptor (CSF1R), partial

In Stock
  • 中文名稱:
    Recombinant Cat Macrophage colony-stimulating factor 1 receptor(CSF1R),partial
  • 貨號:
    CSB-EP006044CA
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; EC 2.7.10.1; Proto-oncogene c-Fms; CD antigen CD115
  • 種屬:
    Felis catus (Cat) (Felis silvestris catus)
  • 蛋白長度:
    Extracellular Domain
  • 來源:
    E.coli
  • 分子量:
    70.8kDa
  • 表達區域:
    20-514
  • 氨基酸序列
    VPVIQPSGPELVVEPGTTVTLRCVGNGSVEWDGPISPHWNLDLDPPSSILTTNNATFQNTGTYHCTEPGNPQGGNATIHLYVKDPARPWKVLAQEVTVLEGQDALLPCLLTDPALEAGVSLVRVRGRPVLRQTNYSFSPWHGFTIHKAKFIENHVYQCSARVDGRTVTSMGIWLKVQKDISGPATLTLEPAELVRIQGEAAQIVCSASNIDVNFDVSLRHGDTKLTISQQSDFHDNRYQKVLTLNLDHVSFQDAGNYSCTATNAWGNHSASMVFRVVESAYLNLTSEQSLLQEVTVGEKVDLQVKVEAYPGLESFNWTYLGPFSDYQDKLDFVTIKDTYRYTSTLSLPRLKRSEAGRYSFLARNAGGQNALTFELTLRYPPEVRVTMTLINGSDTLLCEASGYPQPSVTWVQCRSHTDRCDESAGLVLEDSHSEVLSQVPFHEVIVHSLLAIGTLEHNRTYECRAFNSVGNSSQTFWPISIGAHTQLPDELLFTP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages.
  • 基因功能參考文獻:
    1. the feline CSF-1R was cloned and the responsiveness to CSF-1 and IL-34 from a range of species, was examined. PMID: 23260168
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 最新精品香蕉在线| 大香伊人久久精品一区二区| 日日碰狠狠添天天爽无码 | 欧美又粗又大xxxxbbbb疯狂| 边添小泬边狠狠躁视频| 亚洲性视频免费视频网站| 亚洲 欧美 中文 日韩aⅴ| 亚洲中文字幕无码久久| 疯狂撞击丝袜人妻| 麻豆传煤入口免费进入2023| 97色偷偷色噜噜男人的天堂| 免费人成在线观看网站| 三男一女吃奶添下面视频| 欧美日韩国产一区二区三区不卡| 亚洲欧美人成网站aaa| 久久不见久久见免费视频下载| 成年女性特黄午夜视频免费看| 男女裸体下面进入的免费视频| 国产97色在线 | 日| 中文字幕欧美亚州视频免费 | 亚洲精品乱拍国产一区二区三区| 国产亚洲精品精品国产亚洲综合| 在线看片免费人成视频久网| 欧亚乱熟女一区二区三区在线| 97免费人妻在线视频| 玩弄白嫩少妇xxxxx性| 人妻无码一区二区三区 tv| 亚洲精品夜夜夜妓女网| 久久天天躁狠狠躁夜夜96流白浆| 精品香蕉一区二区三区| 日韩av无码久久一区二区| 一本大道无码av天堂| 久热国产精品视频一区二区三区| 国产又粗又硬又大爽黄老大爷视| 亚洲高清成人av电影网站| 久久精品国产精品亚洲蜜月| 国产成人久久精品77777综合| 国产午费午夜福利200集| 久久国产人妻一区二区免费| 天天爽夜夜爽人人爽曰| 成人内射国产免费观看|