在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Cat Macrophage colony-stimulating factor 1 receptor (CSF1R), partial

  • 中文名稱:
    Recombinant Cat Macrophage colony-stimulating factor 1 receptor(CSF1R),partial
  • 貨號:
    CSB-YP006044CA
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Cat Macrophage colony-stimulating factor 1 receptor(CSF1R),partial
  • 貨號:
    CSB-EP006044CA-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Cat Macrophage colony-stimulating factor 1 receptor(CSF1R),partial
  • 貨號:
    CSB-BP006044CA
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Cat Macrophage colony-stimulating factor 1 receptor(CSF1R),partial
  • 貨號:
    CSB-MP006044CA
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; EC 2.7.10.1; Proto-oncogene c-Fms; CD antigen CD115
  • 種屬:
    Felis catus (Cat) (Felis silvestris catus)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages.
  • 基因功能參考文獻:
    1. the feline CSF-1R was cloned and the responsiveness to CSF-1 and IL-34 from a range of species, was examined. PMID: 23260168
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 国产性生交xxxxx无码| 久久久亚洲欧洲日产无码av| 色综合 图片区 小说区| 成人美女黄网站色大色费全看 | 国色天香中文字幕在线视频| www国产亚洲精品久久麻豆| 亚洲国产最大av| 精品无人区麻豆乱码1区2区| 国产一区二区三区内射高清| 丰满人妻熟妇乱又伦精品| 永久免费的无码中文字幕| 欧美亚洲另类丝袜综合网| 午夜亚洲精品久久一区二区| 久久久久国色av免费看| 无码人妻精品一区二| 日本老熟妇毛茸茸| 在线aⅴ亚洲中文字幕| 久久国产免费观看精品a片| 亚洲色成人网站www永久| 久久av无码精品人妻系列| 又粗又硬整进去好爽视频| 一边做一边喷17p亚洲乱妇50p | 噜噜色综合天天综合网mp3| 日韩欧群交p片内射中文| 国产高潮国产高潮久久久| 国产午夜精品久久精品电影| 亚洲图片校园另激情类小说| 麻豆果冻传媒2021精品传媒一区| 国精产品一区一区三区有限公司杨| 亚洲 日韩 国产 中文有码| 狼友网精品视频在线观看| 欧美性色黄大片| 风流老熟女一区二区三区| 国产成人精品永久免费视频| 校花高潮抽搐冒白浆| 久久精品国产亚洲7777| 国产麻豆放荡av剧情演绎| 婷婷俺也去俺也去官网| 天天天狠天天碰天天爱| 国产精品久久久久久久久久久久午夜片| 国产未发育呦交视频|