在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human FACT complex subunit SPT16 (SUPT16H FACT140 FACTP140)

  • 中文名稱:
  • 貨號:
    CSB-YP022955HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP022955HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP022955HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP022955HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP022955HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    SP16H
  • Uniprot No.:
  • 別名:
    FACT complex subunit SPT16; Chromatin-specific transcription elongation factor 140 kDa subunit; FACT 140 kDa subunit; FACTp140; Facilitates chromatin transcription complex subunit SPT16; hSPT16; SUPT16H FACT140 FACTP140
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
  • 基因功能參考文獻:
    1. present observation and published data suggest that phenotype present in patients with duplication of 14q11.2 region, encompassing the SUPT16H and CHD8 genes, resemble in some extend features described in cases carrying microdeletion of that genomic region PMID: 26834018
    2. FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. PMID: 26842758
    3. In the absence of FACT complex, SSRP1 and SPT16 mRNAs are unstable and inefficiently translated, making reactivation of FACT function unlikely in normal cells. PMID: 23839038
    4. SUPT16H and RNF40 are required for proper DNA end resection and timely DNA repair after double-strand breaks. PMID: 22031019
    5. facilitates RNA polymerase II driven transcription by destabilizing nucleosomal structure so that one histone H2A-H2B dimer is removed during enzyme passage; possesses intrinsic histone chaperone activity and can deposit core histones onto DNA PMID: 12934006
    6. Results demonstrate that elongation by RNA polymerase II through the nucleosomal barrier is minimally dependent upon (1) FACT and (2) the recruitment of PAF and the H2B monoubiquitination machinery. PMID: 16713563
    7. FACT is an integral and conserved component of the endogenous replication machinery, and support a model in which the concerted action of helicase and chromatin-modifying activities promotes chromosome replication. PMID: 16902406
    8. yFACT and Set2 oppose one another during transcriptional initiation at a step involving DNA binding by TBP and TFIIA. PMID: 16977311
    9. SSRP1 has Spt16-dependent and -independent roles in regulating gene transcription in human cells. PMID: 17209051
    10. Data establish FACT as the major regulator involved in H2AX exchange process that is modulated by H2AX phosphorylation and Spt16 ADP-ribosylation. PMID: 18406329

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
  • 蛋白家族:
    Peptidase M24 family, SPT16 subfamily
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11465

    OMIM: 605012

    KEGG: hsa:11198

    STRING: 9606.ENSP00000216297

    UniGene: Hs.213724



主站蜘蛛池模板: 日本公与熄乱理在线播放| 国产自偷自偷免费一区| 青青国产线免观| 中文字幕乱码人在线视频1区| 国产高清视频在线观看97| 好紧好湿好黄的视频| 少妇性饥渴无码a区免费| 国模小婕私拍鲜嫩玉门| 无码国模大尺度视频在线观看 | 免费ā片在线观看| 人妻少妇久久中文字幕456| 不卡av中文字幕手机看| 97se色综合一区二区二区| 久久aaaa片一区二区| 国产成人综合久久三区| 午夜131美女爱做视频| 久久精品亚洲中文字幕无码网站 | 在线 无码 中文字幕 强 乱| 国产成人亚洲精品无码车a| 久久精品水蜜桃av综合天堂| 18禁白丝喷水视频www视频| 亚洲和欧洲一码二码区别7777| 伊人色综合网久久天天| 国产精品福利自产拍久久| 色综合99久久久无码国产精品| 玩弄少妇的肉体k8经典| 精产国品一二三产区9977| 精品亚洲国产成人av制服| 香港aa三级久久三级| 亚洲欧洲无码一区二区三区| 无码中字出轨中文人妻中文中 | 乱色欧美激惰| 青青青国产在线观看免费| 国产大学生粉嫩无套流白浆| 精品少妇人妻av无码久久| 99久久er这里只有精品18| 精品人妻伦一二三区久久aaa片 | 青青草国产精品日韩欧美| 无码av中文一区二区三区| 亚洲熟伦熟女新五十路熟妇| 人人妻人人澡人人爽欧美一区九九|