在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUPT16H Antibody, Biotin conjugated

  • 中文名稱:
    SUPT16H兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA835618LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SUPT16H Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SUPT16H
  • 別名:
    CDC68 antibody; Chromatin specific transcription elongation factor 140 kDa subunit antibody; Chromatin-specific transcription elongation factor 140 kDa subunit antibody; Facilitates chromatin transcription complex subunit SPT16 antibody; FACT 140 kDa subunit antibody; FACT antibody; FACT complex subunit SPT16 antibody; FACTp140 antibody; FLJ10857 antibody; FLJ14010 antibody; hSPT16 antibody; SP16H_HUMAN antibody; Suppressor of Ty 16 homolog antibody; Supt16h antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human FACT complex subunit SPT16 protein (187-282AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
  • 基因功能參考文獻:
    1. present observation and published data suggest that phenotype present in patients with duplication of 14q11.2 region, encompassing the SUPT16H and CHD8 genes, resemble in some extend features described in cases carrying microdeletion of that genomic region PMID: 26834018
    2. FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. PMID: 26842758
    3. In the absence of FACT complex, SSRP1 and SPT16 mRNAs are unstable and inefficiently translated, making reactivation of FACT function unlikely in normal cells. PMID: 23839038
    4. SUPT16H and RNF40 are required for proper DNA end resection and timely DNA repair after double-strand breaks. PMID: 22031019
    5. facilitates RNA polymerase II driven transcription by destabilizing nucleosomal structure so that one histone H2A-H2B dimer is removed during enzyme passage; possesses intrinsic histone chaperone activity and can deposit core histones onto DNA PMID: 12934006
    6. Results demonstrate that elongation by RNA polymerase II through the nucleosomal barrier is minimally dependent upon (1) FACT and (2) the recruitment of PAF and the H2B monoubiquitination machinery. PMID: 16713563
    7. FACT is an integral and conserved component of the endogenous replication machinery, and support a model in which the concerted action of helicase and chromatin-modifying activities promotes chromosome replication. PMID: 16902406
    8. yFACT and Set2 oppose one another during transcriptional initiation at a step involving DNA binding by TBP and TFIIA. PMID: 16977311
    9. SSRP1 has Spt16-dependent and -independent roles in regulating gene transcription in human cells. PMID: 17209051
    10. Data establish FACT as the major regulator involved in H2AX exchange process that is modulated by H2AX phosphorylation and Spt16 ADP-ribosylation. PMID: 18406329

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
  • 蛋白家族:
    Peptidase M24 family, SPT16 subfamily
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 11465

    OMIM: 605012

    KEGG: hsa:11198

    STRING: 9606.ENSP00000216297

    UniGene: Hs.213724



主站蜘蛛池模板: 全国最大成人网| 国产suv精二区| 影音先锋在线亚洲网站| 日本一区二区三区免费播放视频站 | 亚洲精品鲁一鲁一区二区三区| 69sex久久精品国产麻豆| 高潮内射免费看片| 国产在线午夜不卡精品影院| 西西人体做爰大胆性自慰| 国产精品毛片一区二区三区| 国产激情久久久久久熟女老人av | 欧美巨大巨粗黑人性aaaaaa| 亚洲精品动漫免费二区| 岛国4k人妻一区二区三区| 国产精品玖玖玖在线| 一边摸一边抽搐一进一出视频| 国产成人精品无码专区| 久久久久国产精品人妻aⅴ天堂 | 国产av一区最新精品| 日韩 欧美 国产 一区三| 日本一卡2卡3卡4卡免费精品| 久久狠狠色噜噜狠狠狠狠97| 中文字幕无线码一区二区 | 精品一区二区三区自拍图片区| 欧美奶涨边摸边做爰视频| 男人添女人下部高潮视频| 麻豆日产精品卡2卡3卡4卡5卡 | 丰满少妇人妻无码| 艳妇乳肉豪妇荡乳xxx| 97精品久久天干天天| 精品多人p群无码| 无码h肉动漫在线观看| 色情无码一区二区三区| 凸偷窥中国女人洗澡| 日韩乱码人妻无码中文视频| 免费久久99精品国产自在现线| 欧洲美熟女乱又伦av影片| 亚洲乱码日产精品bd在线| 国产久久精品| 国产真实乱对白精彩| 国产精品美女久久久久久2021|