在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUPT16H Antibody, Biotin conjugated

  • 中文名稱:
    SUPT16H兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA835618LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SUPT16H Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SUPT16H
  • 別名:
    CDC68 antibody; Chromatin specific transcription elongation factor 140 kDa subunit antibody; Chromatin-specific transcription elongation factor 140 kDa subunit antibody; Facilitates chromatin transcription complex subunit SPT16 antibody; FACT 140 kDa subunit antibody; FACT antibody; FACT complex subunit SPT16 antibody; FACTp140 antibody; FLJ10857 antibody; FLJ14010 antibody; hSPT16 antibody; SP16H_HUMAN antibody; Suppressor of Ty 16 homolog antibody; Supt16h antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human FACT complex subunit SPT16 protein (187-282AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
  • 基因功能參考文獻:
    1. present observation and published data suggest that phenotype present in patients with duplication of 14q11.2 region, encompassing the SUPT16H and CHD8 genes, resemble in some extend features described in cases carrying microdeletion of that genomic region PMID: 26834018
    2. FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. PMID: 26842758
    3. In the absence of FACT complex, SSRP1 and SPT16 mRNAs are unstable and inefficiently translated, making reactivation of FACT function unlikely in normal cells. PMID: 23839038
    4. SUPT16H and RNF40 are required for proper DNA end resection and timely DNA repair after double-strand breaks. PMID: 22031019
    5. facilitates RNA polymerase II driven transcription by destabilizing nucleosomal structure so that one histone H2A-H2B dimer is removed during enzyme passage; possesses intrinsic histone chaperone activity and can deposit core histones onto DNA PMID: 12934006
    6. Results demonstrate that elongation by RNA polymerase II through the nucleosomal barrier is minimally dependent upon (1) FACT and (2) the recruitment of PAF and the H2B monoubiquitination machinery. PMID: 16713563
    7. FACT is an integral and conserved component of the endogenous replication machinery, and support a model in which the concerted action of helicase and chromatin-modifying activities promotes chromosome replication. PMID: 16902406
    8. yFACT and Set2 oppose one another during transcriptional initiation at a step involving DNA binding by TBP and TFIIA. PMID: 16977311
    9. SSRP1 has Spt16-dependent and -independent roles in regulating gene transcription in human cells. PMID: 17209051
    10. Data establish FACT as the major regulator involved in H2AX exchange process that is modulated by H2AX phosphorylation and Spt16 ADP-ribosylation. PMID: 18406329

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
  • 蛋白家族:
    Peptidase M24 family, SPT16 subfamily
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 11465

    OMIM: 605012

    KEGG: hsa:11198

    STRING: 9606.ENSP00000216297

    UniGene: Hs.213724



主站蜘蛛池模板: 乌克兰少妇xxxx做受| 97精品免费公开在线视频| 人妻熟女久久久久久久| 亚洲一区二区三区av天堂| 亚洲狠狠婷婷综合久久蜜芽| 上司揉捏人妻丰满双乳电影| 性色av一二三天美传媒| 99久久人人爽亚洲精品美女| 四虎精品成人免费视频| 在线涩涩免费观看国产精品| 男女性爽大片视频免费看| 欧洲熟妇色xxxx欧美老妇软件| 久久久无码中文字幕久...| 在线亚洲精品国产一区麻豆| 免费无码成人av片在线| 亚洲成a v人片在线观看| 欧美成人午夜免费全部完| 午夜亚洲乱码伦小说区69堂| 97精品尹人久久大香线蕉| 成年女人免费视频播放体验区| 亚洲在线国产日韩欧美| 国内精品乱码卡一卡2卡三卡新区| 无码专区—va亚洲v专区| 污污污污污污www网站免费| 无码av免费精品一区二区三区| 国产高清japanese在线播放e| 亚洲中文字幕第一页在线| 人妻av无码专区久久| 国产女人被狂躁到高潮小说| 中文在线а天堂| 99久久国产综合精品1| 免费做a爰片久久毛片a片| 天天综合天天爱天天做| 玩弄丰满熟妇xxxxx性60| www成人国产高清内射| 女人裸体做爰免费视频| 免费看成人午夜福利专区| 蜜臀av999无码精品国产专区| 人妻无码久久精品人妻| 黄网站色视频免费国产| 美女裸免费观看网站|