在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUPT16H Antibody

  • 中文名稱:
    SUPT16H兔多克隆抗體
  • 貨號(hào):
    CSB-PA835618LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA835618LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA835618LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SUPT16H Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SUPT16H
  • 別名:
    CDC68 antibody; Chromatin specific transcription elongation factor 140 kDa subunit antibody; Chromatin-specific transcription elongation factor 140 kDa subunit antibody; Facilitates chromatin transcription complex subunit SPT16 antibody; FACT 140 kDa subunit antibody; FACT antibody; FACT complex subunit SPT16 antibody; FACTp140 antibody; FLJ10857 antibody; FLJ14010 antibody; hSPT16 antibody; SP16H_HUMAN antibody; Suppressor of Ty 16 homolog antibody; Supt16h antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human FACT complex subunit SPT16 protein (187-282AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,SUPT16H Antibody (CSB-PA835618LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于SUPT16H Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA835618LB01HU SUPT16H Antibody, HRP conjugated ELISA
    FITC CSB-PA835618LC01HU SUPT16H Antibody, FITC conjugated
    Biotin CSB-PA835618LD01HU SUPT16H Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
  • 基因功能參考文獻(xiàn):
    1. present observation and published data suggest that phenotype present in patients with duplication of 14q11.2 region, encompassing the SUPT16H and CHD8 genes, resemble in some extend features described in cases carrying microdeletion of that genomic region PMID: 26834018
    2. FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. PMID: 26842758
    3. In the absence of FACT complex, SSRP1 and SPT16 mRNAs are unstable and inefficiently translated, making reactivation of FACT function unlikely in normal cells. PMID: 23839038
    4. SUPT16H and RNF40 are required for proper DNA end resection and timely DNA repair after double-strand breaks. PMID: 22031019
    5. facilitates RNA polymerase II driven transcription by destabilizing nucleosomal structure so that one histone H2A-H2B dimer is removed during enzyme passage; possesses intrinsic histone chaperone activity and can deposit core histones onto DNA PMID: 12934006
    6. Results demonstrate that elongation by RNA polymerase II through the nucleosomal barrier is minimally dependent upon (1) FACT and (2) the recruitment of PAF and the H2B monoubiquitination machinery. PMID: 16713563
    7. FACT is an integral and conserved component of the endogenous replication machinery, and support a model in which the concerted action of helicase and chromatin-modifying activities promotes chromosome replication. PMID: 16902406
    8. yFACT and Set2 oppose one another during transcriptional initiation at a step involving DNA binding by TBP and TFIIA. PMID: 16977311
    9. SSRP1 has Spt16-dependent and -independent roles in regulating gene transcription in human cells. PMID: 17209051
    10. Data establish FACT as the major regulator involved in H2AX exchange process that is modulated by H2AX phosphorylation and Spt16 ADP-ribosylation. PMID: 18406329

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
  • 蛋白家族:
    Peptidase M24 family, SPT16 subfamily
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11465

    OMIM: 605012

    KEGG: hsa:11198

    STRING: 9606.ENSP00000216297

    UniGene: Hs.213724



主站蜘蛛池模板: 日本丰满护士videossexhd| 2018亚洲а∨天堂| 色老头精品午夜福利视频| 欧美日韩精品一区二区三区高清视频 | 国产亚洲产品影市在线产品| 日本乱子人伦在线视频| 亚洲欧美日本久久综合网站| 日韩欧美亚洲中文乱码| 国外亚洲成av人片在线观看| 日本三级欧美三级人妇视频黑白配| 欧洲免费无线码在线一区| 99久e在线精品视频在线| 麻豆md0077饥渴少妇| 国产精品人妻一区夜夜爱| 天天躁日日躁狠狠久久| 天堂va视频一区二区| 激情内射亚州一区二区三区爱妻| 麻豆果冻传媒精品| 久久无码中文字幕无码| 亚洲男人的天堂在线aⅴ视频| 亚洲 欧美 日韩 国产综合 在线| 99久久国语露脸精品国产 | 无码三级国产三级在线电影| 五十路丰满中年熟女中出| 国产成a人亚洲精品无码久久网| 国产jjzzjjzz视频全部免费| 潮喷大喷水系列无码久久精品| 九九精品无码专区免费| 荫蒂添的好舒服视频囗交| 一本久久伊人热热精品中文字幕 | 真人做人试看60分钟免费| 8ⅹ8x擦拨擦拨成人免费视频| 麻豆精品国产熟妇aⅴ一区| 国产成人三级一区二区在线观看一 | 免费人成黄页在线观看国产 | 国产成人精品日本亚洲成熟| 成人动漫综合网| 亚洲乱亚洲乱妇中文影视| 18禁无遮挡羞羞污污污污网站| 色综合久久一区二区三区| 久久婷婷激情综合色综合俺也去 |