在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUN2 Recombinant Monoclonal Antibody

  • 中文名稱:
    SUN2 Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA084035A0HU
  • 規(guī)格:
    ¥1320
  • 圖片:
    • IHC image of CSB-RA084035A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing jurkat cells stained with CSB-RA084035A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2), SUN2, FRIGG KIAA0668 RAB5IP UNC84B
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    A synthesized peptide from human SUN2 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    3B10
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC, FC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
  • 基因功能參考文獻:
    1. These results demonstrate that SUN2 is required for the optimal activation and proliferation of primary CD4 T cells and suggest that the disruption of these processes explains the contribution of endogenous SUN2 to HIV infection in primary lymphocytes and show that CypA is not required for the decreased infection observed in SUN2-silenced cells. PMID: 28077629
    2. SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer PMID: 26658802
    3. SUN2 overexpression perturbs both nuclear shape and early events of HIV infection PMID: 26865710
    4. SUN2 as a tumor suppressor mediates miR-221 and miR-222 functions in central nervous system embryonal tumors. PMID: 24832085
    5. the crystal structure of the SUN2 protein SUN domain PMID: 22170055
    6. Data found that expression of lamin A but not lamin C partly restored the nuclear envelope localization of SUN2. PMID: 21655223
    7. Data suggest that SUN2 represents the first mammalian inner nuclear membrane (INM) protein relying on a functional nuclear localization signal, a Golgi retrieval signal and a perinuclear domain to mediate targeting to the INM. PMID: 20551905

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus inner membrane; Single-pass type II membrane protein. Nucleus envelope. Endosome membrane; Single-pass type II membrane protein.
  • 組織特異性:
    Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14210

    OMIM: 613569

    KEGG: hsa:25777

    STRING: 9606.ENSP00000385616

    UniGene: Hs.517622



主站蜘蛛池模板: 国产亚洲一卡2卡3卡4卡网站| 中字幕久久久人妻熟女天美传媒| 18禁超污无遮挡无码网址| 色欲aⅴ 无码| 日韩一区二区三区四区区区| 国产午夜精品一区二区三区不卡 | 国产精品99精品无码视亚| 天天噜噜噜在线视频| 久久99精品久久久久婷婷暖| 亚洲高清无码加勒比| 无码被窝影院午夜看片爽爽jk| 男女爽爽无遮挡午夜视频| 无套中出极品少妇白浆| 国产精品久久久久久亚洲影视内衣| 少妇午夜啪爽嗷嗷叫视频| 国内精品伊人久久久久影院对白| 成人无码视频免费播放| 男人扒开女人腿桶到爽免费 | 国产成人精品2021| 中文字幕人妻熟女av| 又色又爽又黄的视频女女| 国产做爰xxxⅹ久久久精华液| 99精品电影一区二区免费看| 亚洲图片自拍偷图区| 99视频精品全部免费免费观看| 综合色一色综合久久网| 漂亮人妻被中出中文字幕| 色噜噜狠狠一区二区三区| 久久精品人人槡人妻人| 18禁超污无遮挡无码网址| 成视频年人黄网站免费视频 | 日日av拍夜夜添久久免费| 51国偷自产一区二区三区| 日韩乱码人妻无码中文字幕视频| 成 人 黄 色 大片| 无码午夜人妻一区二区不卡视频| 国产成人久久777777| 精品无码一区二区三区爱欲九九 | 996久久国产精品线观看| 玩弄丰满熟妇xxxxx性60| 欧美日韩亚洲国产欧美电影 |