在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUN2 Antibody, Biotin conjugated

  • 中文名稱:
    SUN2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA883386LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SUN2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    SUN2; FRIGG; KIAA0668; RAB5IP; UNC84B; SUN domain-containing protein 2; Protein unc-84 homolog B; Rab5-interacting protein; Rab5IP; Sad1/unc-84 protein-like 2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human SUN domain-containing protein 2 protein (45-155AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
  • 基因功能參考文獻:
    1. These results demonstrate that SUN2 is required for the optimal activation and proliferation of primary CD4 T cells and suggest that the disruption of these processes explains the contribution of endogenous SUN2 to HIV infection in primary lymphocytes and show that CypA is not required for the decreased infection observed in SUN2-silenced cells. PMID: 28077629
    2. SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer PMID: 26658802
    3. SUN2 overexpression perturbs both nuclear shape and early events of HIV infection PMID: 26865710
    4. SUN2 as a tumor suppressor mediates miR-221 and miR-222 functions in central nervous system embryonal tumors. PMID: 24832085
    5. the crystal structure of the SUN2 protein SUN domain PMID: 22170055
    6. Data found that expression of lamin A but not lamin C partly restored the nuclear envelope localization of SUN2. PMID: 21655223
    7. Data suggest that SUN2 represents the first mammalian inner nuclear membrane (INM) protein relying on a functional nuclear localization signal, a Golgi retrieval signal and a perinuclear domain to mediate targeting to the INM. PMID: 20551905

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus inner membrane; Single-pass type II membrane protein. Nucleus envelope. Endosome membrane; Single-pass type II membrane protein.
  • 組織特異性:
    Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.
  • 數據庫鏈接:

    HGNC: 14210

    OMIM: 613569

    KEGG: hsa:25777

    STRING: 9606.ENSP00000385616

    UniGene: Hs.517622



主站蜘蛛池模板: 成人三级视频在线观看一区二区| 狠狠色丁香婷婷综合尤物| 国产模特嫩模私拍视频在线| 韩国三级l中文字幕无码| 午夜一区一品日本| 欧美成人精品第一区二区三区| www亚洲精品久久久乳| 在线综合亚洲欧美日韩| www内射国产在线观看| 粗大的内捧猛烈进出视频| 国内少妇毛片视频| 国产乱子伦三级在线播放| 最新网站亚洲人成无码| 欧洲美熟女乱又伦av| 国产乱子伦农村xxxx| 粗大挺进尤物人妻中文字幕 | 狠狠色噜噜狠狠狠888777米奇| 99热精品毛片全部国产无缓冲| 精品国产人成亚洲区| 亚洲毛片不卡av在线播放一区| 麻豆国产成人av在线播放| 国产精品亚洲a∨天堂不卡| 亚洲色大成网站www永久男同| 无码人妻aⅴ一区二区三区有奶水| 欧洲丰满少妇a毛片| 99re久久精品国产首页| 少妇内射高潮福利炮| 碰超免费人妻中文字幕| 亚洲国产品综合人成综合网站| 亚洲精品中文字幕乱码| 日韩人妻无码一区二区三区久久99 | 久久久久成人精品免费播放动漫| 亚洲性夜夜天天天| 国产av偷闻女邻居内裤被发现| 熟妇高潮喷沈阳45熟妇高潮喷 | 亚洲va无码va在线va天堂| 国产av丝袜一区二区三区| 国产高潮视频在线观看| 一本本月无码-| 国产婷婷精品av在线| 国产欧美日韩精品丝袜高跟鞋|