在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUN2 Antibody, HRP conjugated

  • 中文名稱:
    SUN2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA883386LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SUN2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    SUN2; FRIGG; KIAA0668; RAB5IP; UNC84B; SUN domain-containing protein 2; Protein unc-84 homolog B; Rab5-interacting protein; Rab5IP; Sad1/unc-84 protein-like 2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human SUN domain-containing protein 2 protein (45-155AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
  • 基因功能參考文獻:
    1. These results demonstrate that SUN2 is required for the optimal activation and proliferation of primary CD4 T cells and suggest that the disruption of these processes explains the contribution of endogenous SUN2 to HIV infection in primary lymphocytes and show that CypA is not required for the decreased infection observed in SUN2-silenced cells. PMID: 28077629
    2. SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer PMID: 26658802
    3. SUN2 overexpression perturbs both nuclear shape and early events of HIV infection PMID: 26865710
    4. SUN2 as a tumor suppressor mediates miR-221 and miR-222 functions in central nervous system embryonal tumors. PMID: 24832085
    5. the crystal structure of the SUN2 protein SUN domain PMID: 22170055
    6. Data found that expression of lamin A but not lamin C partly restored the nuclear envelope localization of SUN2. PMID: 21655223
    7. Data suggest that SUN2 represents the first mammalian inner nuclear membrane (INM) protein relying on a functional nuclear localization signal, a Golgi retrieval signal and a perinuclear domain to mediate targeting to the INM. PMID: 20551905

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus inner membrane; Single-pass type II membrane protein. Nucleus envelope. Endosome membrane; Single-pass type II membrane protein.
  • 組織特異性:
    Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.
  • 數據庫鏈接:

    HGNC: 14210

    OMIM: 613569

    KEGG: hsa:25777

    STRING: 9606.ENSP00000385616

    UniGene: Hs.517622



主站蜘蛛池模板: 亚洲欧美不卡高清在线观看| 亚洲一本大道av久在线播放| 国产情侣真实54分钟在线| 欧美伦费免费全部午夜最新| 久久久亚洲精品一区二区三区| 欧美成人免费一区二区| 国产av无码专区亚洲精品| 国产婷婷亚洲999精品小说| 久久综合色老色| 97久久精品人妻人人搡人人玩| 少妇愉情理伦片高潮日本| 曰本大码熟中文字幕| 国产精品玖玖玖在线| 久久精品国产99国产精品| 精品无码国产自产拍在线观看蜜| 国产 | 欧洲野花视频欧洲1| 日本一区不卡高清更新二区| 伊人久久精品一区二区三区| 久久99精品国产.久久久久| 在线视频 亚太 国产 欧美 一区二区| 狠狠色噜噜狠狠狠777米奇888| 午夜影视免费| 日本丰满少妇xxxx| 97精品国产久热在线观看| 少妇的丰满人妻hd高清| 国产黄大片在线观看画质优化| 亚洲香蕉视频天天爽| 亚洲制服丝袜自拍中文字幕| 久久精品无码专区免费| 精品无码一区二区三区爱欲九九 | 疯狂撞击丝袜人妻| 国产白嫩漂亮美女在线观看| 欧美不卡视频一区发布| 国产成人久久精品二区三区| 亚洲精品乱码久久久久久| 亚洲国产中文曰韩丝袜| 亚洲一区二区三区av天堂| 欧美老肥妇做爰bbww| 久久免费视频精品在线| 亚洲人成伊人成综合网久久久| 国产色婷婷五月精品综合在线|