在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUN2 Antibody

  • 中文名稱:
    SUN2兔多克隆抗體
  • 貨號(hào):
    CSB-PA883386LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, Rat lung tissue, Mouse liver tissue
      All lanes: SUN2 antibody at 4.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 81, 83, 80 kDa
      Observed band size: 81 kDa
    • IHC image of CSB-PA883386LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA883386LA01HU diluted at 1:200 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SUN2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    SUN2; FRIGG; KIAA0668; RAB5IP; UNC84B; SUN domain-containing protein 2; Protein unc-84 homolog B; Rab5-interacting protein; Rab5IP; Sad1/unc-84 protein-like 2
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human SUN domain-containing protein 2 protein (45-155AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,SUN2 Antibody (CSB-PA883386LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于SUN2 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA883386LB01HU SUN2 Antibody, HRP conjugated ELISA
    FITC CSB-PA883386LC01HU SUN2 Antibody, FITC conjugated
    Biotin CSB-PA883386LD01HU SUN2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
  • 基因功能參考文獻(xiàn):
    1. These results demonstrate that SUN2 is required for the optimal activation and proliferation of primary CD4 T cells and suggest that the disruption of these processes explains the contribution of endogenous SUN2 to HIV infection in primary lymphocytes and show that CypA is not required for the decreased infection observed in SUN2-silenced cells. PMID: 28077629
    2. SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer PMID: 26658802
    3. SUN2 overexpression perturbs both nuclear shape and early events of HIV infection PMID: 26865710
    4. SUN2 as a tumor suppressor mediates miR-221 and miR-222 functions in central nervous system embryonal tumors. PMID: 24832085
    5. the crystal structure of the SUN2 protein SUN domain PMID: 22170055
    6. Data found that expression of lamin A but not lamin C partly restored the nuclear envelope localization of SUN2. PMID: 21655223
    7. Data suggest that SUN2 represents the first mammalian inner nuclear membrane (INM) protein relying on a functional nuclear localization signal, a Golgi retrieval signal and a perinuclear domain to mediate targeting to the INM. PMID: 20551905

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus inner membrane; Single-pass type II membrane protein. Nucleus envelope. Endosome membrane; Single-pass type II membrane protein.
  • 組織特異性:
    Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 14210

    OMIM: 613569

    KEGG: hsa:25777

    STRING: 9606.ENSP00000385616

    UniGene: Hs.517622



主站蜘蛛池模板: 色在线 | 国产| 国内精品久久久久影院优| 最新在线精品国自产拍视频| 内射精品无码中文字幕| 日本伊人色综合网| 日本精品αv中文字幕| 一二三区乱码不卡手机版| 在教室伦流澡到高潮hgl动漫| 中文字幕精品亚洲人成在线| 国产精品亚洲一区二区| 中文幕无线码中文字蜜桃| 亚洲旡码a∨一区二区三区| 国产美女精品视频线免费播放软件 | 国产亚州精品女人久久久久久| 自愉自愉产区二十四区| 亚洲欧美日韩国产综合一区二区| 久久国产免费观看精品3| 中文字幕亚洲码在线观看| 国产精品久久午夜夜伦鲁鲁| 国产精品亚洲一区二区无码 | 国产精品天干在线观看| 久久亚洲国产成人精品无码区 | 九九精品无码专区免费| 麻豆亚洲一区| 亚洲中文在线播放一区| 日本高清www无色夜在线视频| 亚洲国产精品尤物yw在线观看| 天天躁日日躁狠狠很躁| 丰满日韩放荡少妇无码视频| 久久综合色老色| 性色av一区二区三区无码| 亚洲一卡2卡3卡4卡 精品| 日本熟妇hdsex视频| 无码国内精品久久综合88| 97精品人妻一区二区三区香蕉| 国产精品嫩草影院久久| 亚洲色成人影院在线观看| 色拍拍欧美视频在线看| 久久超碰色中文字幕超清| 欧美丰满熟妇xxxx性ppx人| 久久欧美一区二区三区性生奴|