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SLC25A12 Recombinant Monoclonal Antibody

  • 中文名稱：
    SLC25A12重組抗體
  • 貨號：
    CSB-RA912385A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate, A549 whole cell lysate
      All lanes: SLC25A12 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 75, 63 kDa
      Observed band size: 72-80 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA912385A0HU是針對SLC25A12靶點研發(fā)的重組單克隆抗體，適用于ELISA和Western Blot（WB）等實驗場景。SLC25A12是線粒體溶質(zhì)載體蛋白家族成員，作為鈣結(jié)合天冬氨酸/谷氨酸載體，參與調(diào)控線粒體膜間代謝物轉(zhuǎn)運及細(xì)胞能量代謝平衡，其功能異常與神經(jīng)系統(tǒng)發(fā)育及線粒體相關(guān)疾病機制研究密切相關(guān)。本抗體通過重組表達技術(shù)制備，經(jīng)嚴(yán)格驗證可在WB實驗中特異性識別天然及過表達的SLC25A12蛋白，推薦使用稀釋比例為1:500至1:2000，實驗結(jié)果顯示清晰的目標(biāo)條帶且背景信號低，適用于檢測多種哺乳動物細(xì)胞或組織樣本。該產(chǎn)品可為研究線粒體代謝調(diào)控、神經(jīng)元能量穩(wěn)態(tài)及鈣信號傳導(dǎo)等領(lǐng)域的科研工作者提供可靠工具，支持包括蛋白表達分析、信號通路探索及分子互作研究在內(nèi)的基礎(chǔ)科研應(yīng)用。
  • Uniprot No.：
  • 基因名：
    SLC25A12
  • 別名：
    Calcium-binding mitochondrial carrier protein Aralar1 (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12), SLC25A12, ARALAR1
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human SLC25A12
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    10B12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
  • 基因功能參考文獻：
    1. Genetic variants of SLC25A12 may be associated with risks for childhood ASD. PMID: 28536923
    2. The features of AGC1 structure and function in physiology and pathology, regulation by calcium, dependency on mitochondrial membrane potential, role in cancer cells, and tissue specificity are reviewed. AGC1 is involved in the glutamate-mediated excitotoxicity in neurons and AGC gene or protein alterations were discovered in rare human diseases. Review. PMID: 27132995
    3. Sensitivity analyses including only studies with family-based design demonstrated significant association between autism spectrum disorders and SNPs rs2292813 and rs2056202. In contrast, sensitivity analyses including case-control design studies only failed to find a significant association. Review. PMID: 25663199
    4. rs2056202 and rs2292813 in SLC25A12 may contribute significantly to autism spectrum disorders risk. PMID: 25921325
    5. Structure of the calcium bound and calcium free N- and C-terminal domains is described, elucidating the mechanism of calcium regulation. PMID: 25410934
    6. The physiological roles of AGC1, its links to calcium homeostasis, and its involvement in autism pathogenesis, are reviewed. PMID: 21691713
    7. This study found no differences in the allele, genotype, or haplotype frequencies of these two SNPs between patients and controls. PMID: 19913066
    8. Variants of the AGC1-encoding SLC25A12 gene were neither correlated with AGC activation nor associated with autism-spectrum disorders in 309 simplex and 17 multiplex families. PMID: 18607376
    9. SLC25A12 gene is linked to autism PMID: 15056512
    10. Aralar1 has a role in determining glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells PMID: 15494407
    11. These results suggest that SLC25A12 is not a major contributor to autism risk in these families. PMID: 16648338
    12. it is unlikely that the SLC25A12 polymorphisms investigated play a substantial role in conferring susceptibility to schizophrenia PMID: 17693006
    13. rs2056202 polymorphism in SLC25A12 may be associated with levels of routines and rituals in autism and related disorders PMID: 17894412
    14. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. PMID: 18180767
    15. SLC25A12 gene is associated with autism. PMID: 19360665

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  • 相關(guān)疾病：
    Epileptic encephalopathy, early infantile, 39 (EIEE39)
  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性：
    Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10982

    OMIM: 603667

    KEGG: hsa:8604

    STRING: 9606.ENSP00000388658

    UniGene: Hs.470608



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