在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. SLC25A12 Recombinant Monoclonal Antibody

SLC25A12 Recombinant Monoclonal Antibody

  • 中文名稱：
    SLC25A12重組抗體
  • 貨號：
    CSB-RA912385A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate, A549 whole cell lysate
      All lanes: SLC25A12 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 75, 63 kDa
      Observed band size: 72-80 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA912385A0HU是針對SLC25A12靶點研發(fā)的重組單克隆抗體，適用于ELISA和Western Blot（WB）等實驗場景。SLC25A12是線粒體溶質(zhì)載體蛋白家族成員，作為鈣結(jié)合天冬氨酸/谷氨酸載體，參與調(diào)控線粒體膜間代謝物轉(zhuǎn)運及細(xì)胞能量代謝平衡，其功能異常與神經(jīng)系統(tǒng)發(fā)育及線粒體相關(guān)疾病機制研究密切相關(guān)。本抗體通過重組表達技術(shù)制備，經(jīng)嚴(yán)格驗證可在WB實驗中特異性識別天然及過表達的SLC25A12蛋白，推薦使用稀釋比例為1:500至1:2000，實驗結(jié)果顯示清晰的目標(biāo)條帶且背景信號低，適用于檢測多種哺乳動物細(xì)胞或組織樣本。該產(chǎn)品可為研究線粒體代謝調(diào)控、神經(jīng)元能量穩(wěn)態(tài)及鈣信號傳導(dǎo)等領(lǐng)域的科研工作者提供可靠工具，支持包括蛋白表達分析、信號通路探索及分子互作研究在內(nèi)的基礎(chǔ)科研應(yīng)用。
  • Uniprot No.：
  • 基因名：
    SLC25A12
  • 別名：
    Calcium-binding mitochondrial carrier protein Aralar1 (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12), SLC25A12, ARALAR1
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human SLC25A12
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    10B12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
  • 基因功能參考文獻：
    1. Genetic variants of SLC25A12 may be associated with risks for childhood ASD. PMID: 28536923
    2. The features of AGC1 structure and function in physiology and pathology, regulation by calcium, dependency on mitochondrial membrane potential, role in cancer cells, and tissue specificity are reviewed. AGC1 is involved in the glutamate-mediated excitotoxicity in neurons and AGC gene or protein alterations were discovered in rare human diseases. Review. PMID: 27132995
    3. Sensitivity analyses including only studies with family-based design demonstrated significant association between autism spectrum disorders and SNPs rs2292813 and rs2056202. In contrast, sensitivity analyses including case-control design studies only failed to find a significant association. Review. PMID: 25663199
    4. rs2056202 and rs2292813 in SLC25A12 may contribute significantly to autism spectrum disorders risk. PMID: 25921325
    5. Structure of the calcium bound and calcium free N- and C-terminal domains is described, elucidating the mechanism of calcium regulation. PMID: 25410934
    6. The physiological roles of AGC1, its links to calcium homeostasis, and its involvement in autism pathogenesis, are reviewed. PMID: 21691713
    7. This study found no differences in the allele, genotype, or haplotype frequencies of these two SNPs between patients and controls. PMID: 19913066
    8. Variants of the AGC1-encoding SLC25A12 gene were neither correlated with AGC activation nor associated with autism-spectrum disorders in 309 simplex and 17 multiplex families. PMID: 18607376
    9. SLC25A12 gene is linked to autism PMID: 15056512
    10. Aralar1 has a role in determining glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells PMID: 15494407
    11. These results suggest that SLC25A12 is not a major contributor to autism risk in these families. PMID: 16648338
    12. it is unlikely that the SLC25A12 polymorphisms investigated play a substantial role in conferring susceptibility to schizophrenia PMID: 17693006
    13. rs2056202 polymorphism in SLC25A12 may be associated with levels of routines and rituals in autism and related disorders PMID: 17894412
    14. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. PMID: 18180767
    15. SLC25A12 gene is associated with autism. PMID: 19360665

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Epileptic encephalopathy, early infantile, 39 (EIEE39)
  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性：
    Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10982

    OMIM: 603667

    KEGG: hsa:8604

    STRING: 9606.ENSP00000388658

    UniGene: Hs.470608



主站蜘蛛池模板： 久久精品99无色码中文字幕| 五月天激情电影| 无码高潮又爽又黄a片软件| 国产成人精品三级在线影院| 国产精品自在拍首页视频| 一本大道熟女人妻中文字幕在线| 一本本月无码-| 国产 一二三四五六| 亚洲中文字幕久久精品无码va| 欧美精品18videosex性欧| 亚洲男人的天堂av手机在线观看| 国产日韩欧美亚欧在线| 黑人上司粗大拔不出来电影| 人人妻人人爽日日人人| 伊人久久大香线蕉av五月天宝贝| 国产超碰人人爽人人做| 国产精品综合一区二区三区| 婷婷伊人久久大香线蕉av| 热99re久久精品| 日韩av高清无码| 天天躁夜夜躁狠狠躁2021| 亚洲熟妇无码av不卡在线| 业余 自由 性别 成熟偷窥| 四虎国产精品亚洲一区久久特色 | 亚洲午夜精品一区二区| 西西444www大胆无码视频| 日韩欧美偷拍高跟鞋精品一区| av天堂亚洲区无码先锋影音| 欧美乱大交xxxxx潮喷l头像| 久久亚洲精品无码播放 | 中国熟女仑乱hd| 伊伊人成亚洲综合人网7777| 人妻丝袜中文无码av影音先锋专区| 亚洲国产成人av网站| 2020精品国产户外| 国产成人精品视频ⅴa片软件竹菊| 人妻熟女一二三区夜夜爱| 狠狠狠色丁香综合婷婷久久| 久青青视频在线观看久| 三男一女吃奶添下面视频 | 中国凸偷窥xxxx自由视频|