在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC25A12 Antibody

  • 中文名稱:
    SLC25A12兔多克隆抗體
  • 貨號:
    CSB-PA099323
  • 規格:
    ¥2024
  • 圖片:
    • Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue using CMC1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC25A12 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC25A12
  • 別名:
    SLC25A12; ARALAR1; Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human CMC1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
  • 基因功能參考文獻:
    1. Genetic variants of SLC25A12 may be associated with risks for childhood ASD. PMID: 28536923
    2. The features of AGC1 structure and function in physiology and pathology, regulation by calcium, dependency on mitochondrial membrane potential, role in cancer cells, and tissue specificity are reviewed. AGC1 is involved in the glutamate-mediated excitotoxicity in neurons and AGC gene or protein alterations were discovered in rare human diseases. Review. PMID: 27132995
    3. Sensitivity analyses including only studies with family-based design demonstrated significant association between autism spectrum disorders and SNPs rs2292813 and rs2056202. In contrast, sensitivity analyses including case-control design studies only failed to find a significant association. Review. PMID: 25663199
    4. rs2056202 and rs2292813 in SLC25A12 may contribute significantly to autism spectrum disorders risk. PMID: 25921325
    5. Structure of the calcium bound and calcium free N- and C-terminal domains is described, elucidating the mechanism of calcium regulation. PMID: 25410934
    6. The physiological roles of AGC1, its links to calcium homeostasis, and its involvement in autism pathogenesis, are reviewed. PMID: 21691713
    7. This study found no differences in the allele, genotype, or haplotype frequencies of these two SNPs between patients and controls. PMID: 19913066
    8. Variants of the AGC1-encoding SLC25A12 gene were neither correlated with AGC activation nor associated with autism-spectrum disorders in 309 simplex and 17 multiplex families. PMID: 18607376
    9. SLC25A12 gene is linked to autism PMID: 15056512
    10. Aralar1 has a role in determining glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells PMID: 15494407
    11. These results suggest that SLC25A12 is not a major contributor to autism risk in these families. PMID: 16648338
    12. it is unlikely that the SLC25A12 polymorphisms investigated play a substantial role in conferring susceptibility to schizophrenia PMID: 17693006
    13. rs2056202 polymorphism in SLC25A12 may be associated with levels of routines and rituals in autism and related disorders PMID: 17894412
    14. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. PMID: 18180767
    15. SLC25A12 gene is associated with autism. PMID: 19360665

    顯示更多

    收起更多

  • 相關疾病:
    Epileptic encephalopathy, early infantile, 39 (EIEE39)
  • 亞細胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性:
    Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney.
  • 數據庫鏈接:

    HGNC: 10982

    OMIM: 603667

    KEGG: hsa:8604

    STRING: 9606.ENSP00000388658

    UniGene: Hs.470608



主站蜘蛛池模板: 午夜性色吃奶添下面69影院 | 无人区一线二线三线乱码| 香蕉在线依人视频| 国产成人无码a区在线观看视频app| 久久国产亚洲精品无码| 成人无码精品1区2区3区免费看| 国产精品99久久精品爆乳| av人摸人人人澡人人超碰小说| 蜜臀av综合网| 丰满少妇aaaaaa爰片毛片| 亚洲成av人片天堂网无码】| 中文人妻熟女乱又乱精品| 国产精品无码久久久久| 久久国产乱子伦精品免费午夜 | 欧美乱码精品一区二区三区| 人妻系列av无码专区| 青青草国产精品人人爱| 国产乱子伦精品无码码专区 | 人妻夜夜爽天天爽三区| 国产精品福利视频萌白酱| 日本免费更新一二三区不卡| 在线成 人av影院| 午夜亚洲福利在线老司机| 无码人妻精品一区二区三区99不卡 | 亚洲va久久久噜噜噜久久男同| 国产精品一区二区av片| 午夜精品一区二区三区在线视| 国产肥白大熟妇bbbb视频| 欧美人与禽猛交狂配| 国产性―交―乱―色―情人| 国产在线观看免费人成视频| 久久久久高潮综合影院| 国产精品一卡二卡三卡| 久久久水蜜桃国产成人网站| 欧美丰满熟妇多毛xxxxx| 人人超碰人人爱超碰国产| av午夜久久蜜桃传媒软件| 国产亚洲精品久久yy5099| 日本日本乱码伦专区| 国产露脸无套对白在线播放| 樱花草在线社区www韩国|