在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

USP24 Antibody

  • 中文名稱:
    USP24兔多克隆抗體
  • 貨號:
    CSB-PA008356
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    USP24
  • 別名:
    Deubiquitinating enzyme 24 antibody; KIAA1057 antibody; Ubiquitin carboxyl terminal hydrolase 24 antibody; Ubiquitin carboxyl-terminal hydrolase 24 antibody; Ubiquitin specific peptidase 24 antibody; Ubiquitin specific processing protease 24 antibody; Ubiquitin specific protease 24 antibody; Ubiquitin thioesterase 24 antibody; Ubiquitin thiolesterase 24 antibody; Ubiquitin-specific-processing protease 24 antibody; UBP24_HUMAN antibody; Usp24 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human USP24.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron.
  • 基因功能參考文獻:
    1. USP24 level was decreased during the early stage of cancer and the mitotic stage of the cell cycle to regulate its substrates p300, Bax, E2F4 and securin, resulting in decreased cell apoptosis and increased cell cycle progression and, thus, cancer formation. PMID: 27991932
    2. Data show that ubiquitin-specific peptidase 24 (USP24) is highly expressed in cell lines with enhanced malignancy and in late-stage lung cancer clinical samples. PMID: 26568301
    3. USP24 deubiquitinase regulates the DNA damage response by directly targeting the p53 tumor suppressor. PMID: 25578727
    4. the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice. PMID: 25814533
    5. These results suggested that USP24 expression is tightly regulated at its transcription level and NFkappaB plays an important role in this process. PMID: 24286619
    6. The knockdown of USP24 in two human cell lines decreased the steady-state levels of DDB2, indicating that USP24-mediated DDB2 deubiquitination prevents DDB2 degradation. PMID: 23159851
    7. The present study is the first to report a lack of association between SNPs of USP24 and parkinson disease in Han Chinese patients. Other PMID: 22923019
    8. USP24 alone plays a role in PD susceptibility among Taiwanese people >or=60 years of age, or acting synergistically with USP40 and UCHL1 in the total subjects. PMID: 20302855
    9. Data suggest that genetic variants in USP24 affect the risk for late-onset Parkinson disease (PD), which is consistent with the predicted role of the ubiquitination pathway in PD etiology. PMID: 16917932

    顯示更多

    收起更多

  • 蛋白家族:
    Peptidase C19 family
  • 數據庫鏈接:

    HGNC: 12623

    OMIM: 610569

    KEGG: hsa:23358

    STRING: 9606.ENSP00000294383

    UniGene: Hs.477009



主站蜘蛛池模板: 女学生14毛片视频片二毛 | 蜜桃无码一区二区三区| 影音先锋在线资源无码| 8x福利精品第一导航| 亚洲国产成人精品无码一区二区| 免费不卡无码av在线观看| 女人被男人躁得好爽免费视频| 中文字幕乱码亚洲无线三区| 色又黄又爽18禁免费网站现观看 | 少妇午夜啪爽嗷嗷叫视频| 日本无码人妻精品一区二区蜜桃| 久久人午夜亚洲精品无码区| 国产成人青青久久大片| 国产欧美久久一区二区| 1000部精品久久久久久久久| 奇米777四色在线精品| 国产精品亚洲一区二区z| 国产成人无码精品久久久露脸| 夜夜嗨av一区二区三区| 青草视频在线观看视频| 蜜芽av无码精品国产午夜| 国产又爽又大又黄a片| 欧美综合自拍亚洲综合图| 两根大肉大捧一进一出好爽视频| 92国产精品午夜免费福利视频| 日日碰狠狠添天天爽超碰97| 在线精品视频一区二区三区| 国产成人一区二区三区别| 2018年亚洲欧美在线v| 日韩国产成人无码av毛片蜜柚| 国产狂喷潮在线观看| 欧美一夜爽爽爽爽爽爽| 免费人成在线观看视频无码| 18禁免费吃奶摸下激烈视频| 国产av熟女一区二区三区| 色狠狠一区二区三区香蕉| 中文字幕无码精品亚洲资源网| 无码人妻精品一二三区免费| 日本护士毛茸茸高潮| 亚洲午夜成人精品无码app| 极品少妇一区二区三区四区|