在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TMOD1 Antibody

  • 中文名稱:
    TMOD1兔多克隆抗體
  • 貨號:
    CSB-PA023909GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    TMOD1
  • 別名:
    D9S57E antibody; E Tmod antibody; E tropomodulin antibody; E-Tmod antibody; Erythrocyte tropomodulin antibody; ETMOD antibody; MGC124125 antibody; MGC124126 antibody; OTTHUMP00000021743 antibody; TMOD antibody; Tmod1 antibody; TMOD1 protein antibody; TMOD1_HUMAN antibody; Tropomodulin 1 antibody; Tropomodulin-1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TMOD1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
  • 基因功能參考文獻(xiàn):
    1. Tmod1 function in mouse and human erythroblasts, was investigated. PMID: 28729432
    2. The mutation reduced binding affinity for both Lmod2 and Tmod1. The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 provides a molecular rationale for the development of familial dilated cardiomyopathies . PMID: 26873245
    3. Study highlighted a novel TMOD1-mediated link between NF-kappaB activation and MMP13 induction, which accounts in part for the NF-kappaB-dependent malignant phenotype of TNBC. PMID: 25398440
    4. Tmod1 and Tmod3 showed somewhat different tropomyosin-binding site utilization. PMID: 24922351
    5. The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin molecules on each side of the filament. PMID: 25061212
    6. Tropomyosin requires an intact N-terminal coiled coil to interact with this protein PMID: 11964245
    7. levels of TM1, TM2 and TM3 are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase-signaling pathway PMID: 15095301
    8. The N-terminal "KRK ring" may participate in balancing electrostatic force with hydrophobic interaction in dimerization of TM and its binding to E-Tmod. PMID: 16297372
    9. study identifies several amino acid residues on Tmod-1 that are important for its interaction with TM5 (a nonmuscle TM isoform) PMID: 16434395

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Tropomodulin family
  • 組織特異性:
    Highly expressed in the erythrocyte, heart and skeletal muscle.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11871

    OMIM: 190930

    KEGG: hsa:7111

    STRING: 9606.ENSP00000259365

    UniGene: Hs.404289



主站蜘蛛池模板: 18禁免费吃奶摸下激烈视频| 超碰国产精品人人做人人爱| 中文字幕中文有码在线| 国产jjzzjjzz视频全部免费| 国产激情无码视频在线播放| 日日摸日日碰夜夜爽亚洲综合 | 双腿张开被9个男人调教| 日韩伦人妻无码| 久久精品国产首页027007| 国产超碰人人做人人爱| 66lu国产在线观看| 粗大猛烈进出高潮视频免费看 | 亚洲人成在线观看网站不卡| 色香阁综合无码国产在线| 男女下面一进一出无遮挡| 国产精品国产亚洲精品看不卡| 色综合久久无码中文字幕 | 18禁勿入网站入口永久| 国产成人a在线观看视频| 97久久精品人人做人人爽| 色综合99久久久无码国产精品| 亚洲国产欧美在线人成人| 久久精品人人做人人爱爱漫画 | 躁躁躁日日躁| 无码人妻丰满熟妇啪啪7774| 少妇无码av无码一区| 欧美熟妇色ⅹxxx欧美妇| 天天综合网网欲色| 18禁无码永久免费无限制网站| 国产啪精品视频网站免| 人妻一本久道久久综合久久鬼色| 国产97在线 | 亚洲| 秋霞人妻无码中文字幕| 影音先锋啪啪av资源网站| 在线看片人成视频免费无遮挡| 久精品国产欧美亚洲色aⅴ大片 | 丰满少妇夜夜爽爽高潮水 | 亚洲欧美日韩中文播放| 欧美成人性做爰77777| 中文字幕无码乱人伦| 欧美激欧美啪啪片免费看|