在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TCF7L1 Antibody

  • 中文名稱:
    TCF7L1兔多克隆抗體
  • 貨號:
    CSB-PA884626OA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, U251 whole cell lysate, U87 whole cell lysate
      All lanes: TCF7L1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 63 kDa
      Observed band size: 63 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TCF7L1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    bHLHb21 antibody; HMG box transcription factor 3 antibody; HMG box transcription factor antibody; OTTMUSP00000023419 antibody; T cell factor 3 antibody; TCF 3 antibody; TCF-3 antibody; TCF3 antibody; Tcf7l1 antibody; TF7L1_HUMAN antibody; Transcription factor 7 like 1 (T-cell specific, HMG-box) antibody; Transcription factor 7 like 1 antibody; Transcription factor 7-like 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence from Human Transcription factor 7-like 1 protein (80-99AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,TCF7L1 Antibody (CSB-PA884626OA01HU),的標記方式是Non-conjugated。對于TCF7L1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA884626OB01HU TCF7L1 Antibody, HRP conjugated ELISA
    FITC CSB-PA884626OC01HU TCF7L1 Antibody, FITC conjugated
    Biotin CSB-PA884626OD01HU TCF7L1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance.
  • 基因功能參考文獻:
    1. HIPK2 up-regulates transcription by phosphorylating TCF3, a transcriptional repressor, but inhibits transcription by phosphorylating LEF1, a transcriptional activator. PMID: 21285352
    2. Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate. PMID: 23063976
    3. Our results identify TCF3 as a central regulator of tumor growth and initiation. PMID: 23090119
    4. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. PMID: 23492770
    5. TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression. PMID: 24596249
    6. These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers. PMID: 25659031
    7. TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth PMID: 27333864
    8. TCF7L1 plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation PMID: 29361574
    9. Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth. PMID: 28467300
    10. report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects PMID: 26764381
    11. No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression. PMID: 20532534

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    TCF/LEF family
  • 組織特異性:
    Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
  • 數據庫鏈接:

    HGNC: 11640

    OMIM: 604652

    KEGG: hsa:83439

    STRING: 9606.ENSP00000282111

    UniGene: Hs.516297



主站蜘蛛池模板: 免费无码va一区二区三区 | 国产xxxx做受视频| 亚洲综合av色婷婷| 免费h动漫无码网站| 无码人妻丝袜视频在线播免费| 色婷婷五月综合色啪网| 国产精品偷伦视频免费观看了| 非洲黑人最猛性xxxx交| 日韩乱码人妻无码中文字幕久久| 饥渴少妇做私密保健视频| 国产免费福利在线视频| 久久精品国产精品亚洲蜜月| 丰满少妇人妻无码专区| 国精产品一二三区传媒公司| 综合图片亚洲综合网站| 国产精品无码久久av不卡| 中文字幕一区二区三区久久网站 | 欧美精品黑人粗大视频| 久久人人妻人人做人人爽| 欧美变态暴力牲交videos| 国产av福利第一精品| 婷婷成人小说综合专区| 久久久久人妻精品一区三寸蜜桃 | 大陆精大陆国产国语精品| 先锋影音av资源站av| 天堂最新版在线www官网中文地址| 特级aaaaaaaaa毛片免费视频| 日韩精品毛片无码一区到三区| 怡春院久久国语视频免费| 欧美丰满老熟妇乱叫| 精品久久久无码中文字幕 | www内射国产在线观看| 亚洲色爱图小说专区| 国产午夜亚洲精品不卡下载| 亚洲中文字幕无码一久久区| 超碰cao已满18进入离开官网| 人成午夜免费大片| 色悠久久久久综合网国产| 欧美熟妇xxxxx欧美老妇不卡| av无码国产精品麻豆| 情侣激情18内射骚话国产 |