在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TCF7L1 Antibody, HRP conjugated

  • 中文名稱:
    TCF7L1兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA884626OB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) TCF7L1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    bHLHb21 antibody; HMG box transcription factor 3 antibody; HMG box transcription factor antibody; OTTMUSP00000023419 antibody; T cell factor 3 antibody; TCF 3 antibody; TCF-3 antibody; TCF3 antibody; Tcf7l1 antibody; TF7L1_HUMAN antibody; Transcription factor 7 like 1 (T-cell specific, HMG-box) antibody; Transcription factor 7 like 1 antibody; Transcription factor 7-like 1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Peptide sequence from Human Transcription factor 7-like 1 protein (80-99AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance.
  • 基因功能參考文獻(xiàn):
    1. HIPK2 up-regulates transcription by phosphorylating TCF3, a transcriptional repressor, but inhibits transcription by phosphorylating LEF1, a transcriptional activator. PMID: 21285352
    2. Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate. PMID: 23063976
    3. Our results identify TCF3 as a central regulator of tumor growth and initiation. PMID: 23090119
    4. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. PMID: 23492770
    5. TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression. PMID: 24596249
    6. These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers. PMID: 25659031
    7. TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth PMID: 27333864
    8. TCF7L1 plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation PMID: 29361574
    9. Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth. PMID: 28467300
    10. report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects PMID: 26764381
    11. No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression. PMID: 20532534

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    TCF/LEF family
  • 組織特異性:
    Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11640

    OMIM: 604652

    KEGG: hsa:83439

    STRING: 9606.ENSP00000282111

    UniGene: Hs.516297



主站蜘蛛池模板: 国模冰莲自慰肥美胞极品人体图 | 久久久欧美精品激情| 国产麻豆精品传媒av国产婷婷| 亚洲 欧洲 日韩 综合色天使| 男女爽爽无遮挡午夜视频| 久久天天躁狠狠躁夜夜2020一| 天天躁日日躁狠狠躁欧美老妇| 国产精品一区二区av| 久久国产午夜精品理论片| 国产精品无码av不卡顿| 伊人久久综合色| 粗了大了 整进去好爽视频| 忍着娇喘人妻被中出中文字幕| 国产理论剧情大片在线播放| 熟妇人妻无乱码中文字幕| 无码区国产区在线播放| 国产69精品久久久久乱码免费| 又爽又色禁片1000视频免费看| 青青草无码精品伊人久久| 中文字幕美人妻亅u乚一596| 亚洲国产精品特色大片观看完整版| 欧美黑人巨大videos精品男男 | 中文字幕va一区二区三区| 熟女人妻视频| 日韩av无码一区二区三区| 天堂va欧美va亚洲va好看va| 天码人妻一区二区三区| 中国妇女做爰视频| 人妻丝袜av中文系列先锋影音| 国产午夜精华无码网站| 久久综合给合久久97色| 国产精品久线在线观看| 精品亚洲国产成人a片app| 亚洲精品久久av无码麻| 亚洲国产精品美女久久久久| 香蕉成人伊视频在线观看| 亚洲成片在线观看12345| 国产专区免费资源网站| 大乳丰满人妻中文字幕日本| 98视频精品全部国产| 18禁无遮挡无码国产免费网站|