在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TCF7L1 Antibody

  • 中文名稱:
    TCF7L1兔多克隆抗體
  • 貨號:
    CSB-PA737037
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from 3T3 cells, using TCF7L1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TCF7L1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human TCF7L1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance.
  • 基因功能參考文獻:
    1. HIPK2 up-regulates transcription by phosphorylating TCF3, a transcriptional repressor, but inhibits transcription by phosphorylating LEF1, a transcriptional activator. PMID: 21285352
    2. Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate. PMID: 23063976
    3. Our results identify TCF3 as a central regulator of tumor growth and initiation. PMID: 23090119
    4. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. PMID: 23492770
    5. TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression. PMID: 24596249
    6. These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers. PMID: 25659031
    7. TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth PMID: 27333864
    8. TCF7L1 plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation PMID: 29361574
    9. Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth. PMID: 28467300
    10. report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects PMID: 26764381
    11. No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression. PMID: 20532534

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    TCF/LEF family
  • 組織特異性:
    Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
  • 數據庫鏈接:

    HGNC: 11640

    OMIM: 604652

    KEGG: hsa:83439

    STRING: 9606.ENSP00000282111

    UniGene: Hs.516297



主站蜘蛛池模板: 伊人成年网站综合网| 日韩人妻无码精品久久久不卡| 亚洲欧美日韩综合一区二区| 中文天堂在线www最新版官网| 伊人成伊人成综合网222| av中文无码韩国亚洲色偷偷 | 久久午夜无码鲁丝片秋霞| 国产成人无码午夜福利在线直播| 男人猛戳女人30分钟视频大全| 久久精品人人做人人爱爱漫画| 久久综合久色欧美综合狠狠| 久久成人影院精品777| 日本丰满熟妇videossex| 国精产品69永久中国有限| 怡红院av一区二区三区| 久久www免费人成精品| 国产福利男女xx00视频| 久久人人97超碰caoporen| 四虎永久地址www成人| 国产特级毛片aaaaaa| 国产无遮挡乱子伦免费精品| 在线日韩av免费永久观看 | 免费午夜爽爽爽www视频十八禁 | 男人的天堂av社区在线| 欧美精品无码久久久久久| 免费大片黄在线观看| 亚洲一区无码中文字幕乱码| 国产 成人 综合 亚洲 网站| 视频分类 国内精品| 精品国产乱码久久久人妻| 国精品无码av人妻受辱系| 老子影院无码午夜伦不卡| 国产麻花豆剧传媒精品mv在线| 亚洲一区在线日韩在线秋葵| 韩国 日本 亚洲 国产 不卡| 国产精品涩涩涩视频网站| 天堂中文在线资源| 国产av一区二区精品凹凸| 国产第一页浮力影院草草| 97久久精品亚洲中文字幕无码| 久久综合九色综合97网|