在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TCF7L1 Antibody

TCF7L1 Antibody

  • 中文名稱：
    TCF7L1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA060252
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    bHLHb21 antibody; HMG box transcription factor 3 antibody; HMG box transcription factor antibody; OTTMUSP00000023419 antibody; T cell factor 3 antibody; TCF 3 antibody; TCF-3 antibody; TCF3 antibody; Tcf7l1 antibody; TF7L1_HUMAN antibody; Transcription factor 7 like 1 (T-cell specific, HMG-box) antibody; Transcription factor 7 like 1 antibody; Transcription factor 7-like 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TCF-3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance.
  • 基因功能參考文獻(xiàn)：
    1. HIPK2 up-regulates transcription by phosphorylating TCF3, a transcriptional repressor, but inhibits transcription by phosphorylating LEF1, a transcriptional activator. PMID: 21285352
    2. Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate. PMID: 23063976
    3. Our results identify TCF3 as a central regulator of tumor growth and initiation. PMID: 23090119
    4. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. PMID: 23492770
    5. TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression. PMID: 24596249
    6. These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers. PMID: 25659031
    7. TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth PMID: 27333864
    8. TCF7L1 plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation PMID: 29361574
    9. Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth. PMID: 28467300
    10. report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects PMID: 26764381
    11. No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression. PMID: 20532534

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    TCF/LEF family
  • 組織特異性：
    Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 11640

    OMIM: 604652

    KEGG: hsa:83439

    STRING: 9606.ENSP00000282111

    UniGene: Hs.516297



主站蜘蛛池模板： 在办公室被c到呻吟的动态图| 国产96在线 | 欧美| 色偷偷av男人的天堂| 亚洲欧洲成人av每日更新| 久久精品日日躁夜夜躁欧美| 阳茎伸入女人阳道视频| 成视频年人黄网站视频福利| 久久青草成人综合网站| 人妻熟妇乱又伦精品视频无广告| 漂亮人妻洗澡被公强 日日躁| 两个奶头被吃高潮视频| 色偷偷88888欧美精品久久久| 在线天堂中文www官网| 久久久久久国产精品mv| 99久在线国内在线播放免费观看| 国产av无码专区亚汌a√| 国产成人av一区二区三区在线观看 | 日产精品高潮呻吟av久久| 亚洲成av人片天堂网久久| 无码人妻少妇精品无码专区漫画| 丰满熟女人妻一区二区三| 熟妇人妻中文av无码| 欧洲vat一区二区三区| 韩国 日本 亚洲 国产 不卡| 综合图区亚洲欧美另类图片| 99久久免费精品高清特色大片| 18禁止进入1000部高潮网站| 免费无码黄动漫十八禁| 最新亚洲中文av在线不卡| 午夜不卡av免费| 波多野结衣av无码| 四虎影视精品永久在线观看| 四库影院永久国产精品地址| 四虎成人精品永久网站| 18禁黄网站禁片免费观看| 色狠狠色噜噜av天堂一区| 国产成人亚洲高清一区| 日本一丰满一bbw| 无码人妻丰满熟妇区96| 精品一区二区不卡无码av| 国产嘿嘿嘿视频在线观看|