在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SYN1 Antibody

  • 中文名稱:
    SYN1兔多克隆抗體
  • 貨號:
    CSB-PA698387
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA698387(SYN1 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Brain protein 4.1 antibody; SYN 1 antibody; SYN 1a antibody; SYN 1b antibody; SYN I antibody; SYN1 antibody; SYN1_HUMAN antibody; SYN1a antibody; SYN1b antibody; Synapsin 1 antibody; Synapsin I antibody; Synapsin-1 antibody; Synapsin1 antibody; SynapsinI antibody; SYNI antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human SYN1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • 基因功能參考文獻:
    1. Authors identified the c.236 C > G/p.S79W mutation in SYN1 as causative for the non-syndromic ID of the MRX50 family. Accordingly, the in vitro characterization of S79W SynI clearly indicates that the mutation does not interfere with neurodevelopmental aspects, but perturbs spontaneous SV exocytosis, SV clustering and SV lateral mobility along axons. PMID: 28973667
    2. These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. PMID: 27515700
    3. Cerebral malaria causes pre-synaptic excitation and eventually activation of synapsin I, leading to increased neurotransmitter release. PMID: 26823711
    4. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development. PMID: 26204769
    5. The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders. PMID: 24088370
    6. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
    7. Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology. PMID: 23818987
    8. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. PMID: 23406870
    9. The histone modification marks were significantly increased in major depression and this effect was correlated with significant increases in SYN1b gene expression. PMID: 22571925
    10. The allelic frequencies of SYN1 are associated with Korean female schizophrenia. PMID: 22807112
    11. SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function. PMID: 21441247
    12. the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia. PMID: 20921223
    13. The authors propose claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion in HIV-1-infected patients. PMID: 20700059
    14. The results showed that synapsin I was significantly decreased in the stratum radiatum of CA1 subfield and the molecular layer of DG in AD patients. PMID: 14673601
    15. SYN1 nonsense mutation is the likely cause of epileptic and other phenotypes PMID: 14985377
    16. Synapsins and S100A1 interact in nerve terminals where coexpresssed; S100A1 cannot bind SV-associated synapsin I and may function as a cytoplasmic store of monomeric synapsin I; synapsin dimerization and interaction with S100A1 are mutually exclusive PMID: 15147519
    17. This study concluded that the human synapsin I gene is positively regulated by nuclear respiratory factor 1 and mediates the function of nuclear respiratory factor 1 in neurite outgrowth. PMID: 19301426

    顯示更多

    收起更多

  • 相關疾病:
    Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD)
  • 亞細胞定位:
    Cell junction, synapse. Golgi apparatus.
  • 蛋白家族:
    Synapsin family
  • 數據庫鏈接:

    HGNC: 11494

    OMIM: 300491

    KEGG: hsa:6853

    STRING: 9606.ENSP00000295987

    UniGene: Hs.225936



主站蜘蛛池模板: 精品日产一卡2卡三卡4卡在线| 亚洲精品无码不卡在线播he| 久久久亚洲欧洲日产国产成人无码 | 国产aⅴ视频免费观看| 日日碰日日摸夜夜爽无码| 国产成人a区在线观看视频| 无码日韩人妻精品久久蜜桃| 女人张开腿让男人桶爽| 国产日产亚洲系列最新美使用方法 | 欧美激情一区二区成人| 99大香伊乱码一区二区| 巨人精品福利官方导航| 狠狠色综合网久久久久久| 又色又爽又黄的gif动态图| 亚洲一线产区二线产区分布| 国产精品美女久久久久| 夜夜国产亚洲视频香蕉| 四虎影视精品永久在线观看| 又硬又粗进去好爽免费| 欧美性色黄大片手机版| 噜噜色综合噜噜色噜噜色| 东京热毛片无码dvd一二三区| 国产亚洲精aa在线观看| 欧美牲交a欧美牲交aⅴ久久| 国产精品自在线拍国产| 日本伦奷在线播放| 国产午夜福利久久精品| 少妇伦子伦情品无吗| 久久无码中文字幕无码| 中文字幕欧美亚州视频免费 | 亚洲久悠悠色悠在线播放| 欧美 日产 国产在线观看| 亚州久久久久区1区2少妇| 欧美乱妇高清无乱码在线观看| 亚洲一区在线日韩在线秋葵| 最新精品国偷自产在线老年人| 国产精品成人av在线观看| 又粗又黄又硬又爽的免费视频| 国产精品卡1卡2卡3网站| 久久狠狠色噜噜狠狠狠狠97| 亚洲欧美日韩中文久久|