在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-SYN1 (S9) Antibody

  • 中文名稱:
    磷酸化-SYN1 (S9)兔多克隆抗體
  • 貨號:
    CSB-PA000626
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 3T3 cells using Phospho-Synapsin I (S9) Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using Phospho-Synapsin I (S9) Polyclonal Antibody
    • Western blot analysis of HELA KB 293T 3T3 lysis using Phospho-Synapsin I (S9) antibody.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Brain protein 4.1 antibody; SYN 1 antibody; SYN 1a antibody; SYN 1b antibody; SYN I antibody; SYN1 antibody; SYN1_HUMAN antibody; SYN1a antibody; SYN1b antibody; Synapsin 1 antibody; Synapsin I antibody; Synapsin-1 antibody; Synapsin1 antibody; SynapsinI antibody; SYNI antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human Synapsin I around the phosphorylation site of S9.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • 基因功能參考文獻:
    1. Authors identified the c.236 C > G/p.S79W mutation in SYN1 as causative for the non-syndromic ID of the MRX50 family. Accordingly, the in vitro characterization of S79W SynI clearly indicates that the mutation does not interfere with neurodevelopmental aspects, but perturbs spontaneous SV exocytosis, SV clustering and SV lateral mobility along axons. PMID: 28973667
    2. These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. PMID: 27515700
    3. Cerebral malaria causes pre-synaptic excitation and eventually activation of synapsin I, leading to increased neurotransmitter release. PMID: 26823711
    4. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development. PMID: 26204769
    5. The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders. PMID: 24088370
    6. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
    7. Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology. PMID: 23818987
    8. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. PMID: 23406870
    9. The histone modification marks were significantly increased in major depression and this effect was correlated with significant increases in SYN1b gene expression. PMID: 22571925
    10. The allelic frequencies of SYN1 are associated with Korean female schizophrenia. PMID: 22807112
    11. SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function. PMID: 21441247
    12. the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia. PMID: 20921223
    13. The authors propose claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion in HIV-1-infected patients. PMID: 20700059
    14. The results showed that synapsin I was significantly decreased in the stratum radiatum of CA1 subfield and the molecular layer of DG in AD patients. PMID: 14673601
    15. SYN1 nonsense mutation is the likely cause of epileptic and other phenotypes PMID: 14985377
    16. Synapsins and S100A1 interact in nerve terminals where coexpresssed; S100A1 cannot bind SV-associated synapsin I and may function as a cytoplasmic store of monomeric synapsin I; synapsin dimerization and interaction with S100A1 are mutually exclusive PMID: 15147519
    17. This study concluded that the human synapsin I gene is positively regulated by nuclear respiratory factor 1 and mediates the function of nuclear respiratory factor 1 in neurite outgrowth. PMID: 19301426

    顯示更多

    收起更多

  • 相關疾病:
    Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD)
  • 亞細胞定位:
    Cell junction, synapse. Golgi apparatus.
  • 蛋白家族:
    Synapsin family
  • 數據庫鏈接:

    HGNC: 11494

    OMIM: 300491

    KEGG: hsa:6853

    STRING: 9606.ENSP00000295987

    UniGene: Hs.225936



主站蜘蛛池模板: 男女下面一进一出好爽视频| 香蕉久久一区二区三区啪啪| 成人午夜看黄在线尤物成人| 欧美婷婷六月丁香综合| 人妻 偷拍 无码 中文字幕| 亚洲精品中文字幕一区二区三区 | 中文字幕人妻色偷偷久久| 精品久久久噜噜噜久久久| 国产一二三四区乱码免费| 亚洲午夜精品a片一区二区app| 少妇精品无码一区二区免费视频| 狠狠躁夜夜躁人人爽天天天天97| 国产日韩欧美久久久精品图片| 欧美精品a∨在线观看| 爽到高潮无码视频在线观看| 久久欧美一区二区三区性生奴| 人妻人人做人做人人爱| 怡春院久久国语视频免费| 夜夜躁狠狠躁日日躁2022| 亚洲伊人成无码综合网| 摸丰满大乳奶水www免费| 国产激情无码视频在线播放| 久久无码精品一一区二区三区| 亚洲区小说区图片区qvod| 国产亚洲精品aaaa片小说 | 亚洲欧美日韩精品色xxx| 久天啪天天久久99久久| 色天使久久综合给合久久97色 | 丰满少妇做爰视频爽爽和| 欧美老妇与zozoz0交| 国内精品卡一卡二卡三| 亚洲va在线va天堂va欧美va| 欧美精品videossex少妇| 久久精品a亚洲国产v高清不卡| 日本少妇高潮喷水免费可以看| 亚洲成l人在线观看线路| 久在线观看福利视频| 免费无码不卡中文字幕在线| 变态另类牲交乱| 久久国产精品久久久久久| 欧美一夜爽爽爽爽爽爽|