在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SYN1 (Ab-9) Antibody

  • 中文名稱:
    SYN1 (Ab-9)兔多克隆抗體
  • 貨號:
    CSB-PA443245
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from C6 cells using synapsin(Ab-9) Antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SYN1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Peptide sequence around aa.7~11 (R-L-S-D-S) derived from Human SYN1/synapsin.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • 基因功能參考文獻:
    1. Authors identified the c.236 C > G/p.S79W mutation in SYN1 as causative for the non-syndromic ID of the MRX50 family. Accordingly, the in vitro characterization of S79W SynI clearly indicates that the mutation does not interfere with neurodevelopmental aspects, but perturbs spontaneous SV exocytosis, SV clustering and SV lateral mobility along axons. PMID: 28973667
    2. These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. PMID: 27515700
    3. Cerebral malaria causes pre-synaptic excitation and eventually activation of synapsin I, leading to increased neurotransmitter release. PMID: 26823711
    4. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development. PMID: 26204769
    5. The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders. PMID: 24088370
    6. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
    7. Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology. PMID: 23818987
    8. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. PMID: 23406870
    9. The histone modification marks were significantly increased in major depression and this effect was correlated with significant increases in SYN1b gene expression. PMID: 22571925
    10. The allelic frequencies of SYN1 are associated with Korean female schizophrenia. PMID: 22807112
    11. SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function. PMID: 21441247
    12. the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia. PMID: 20921223
    13. The authors propose claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion in HIV-1-infected patients. PMID: 20700059
    14. The results showed that synapsin I was significantly decreased in the stratum radiatum of CA1 subfield and the molecular layer of DG in AD patients. PMID: 14673601
    15. SYN1 nonsense mutation is the likely cause of epileptic and other phenotypes PMID: 14985377
    16. Synapsins and S100A1 interact in nerve terminals where coexpresssed; S100A1 cannot bind SV-associated synapsin I and may function as a cytoplasmic store of monomeric synapsin I; synapsin dimerization and interaction with S100A1 are mutually exclusive PMID: 15147519
    17. This study concluded that the human synapsin I gene is positively regulated by nuclear respiratory factor 1 and mediates the function of nuclear respiratory factor 1 in neurite outgrowth. PMID: 19301426

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD)
  • 亞細胞定位:
    Cell junction, synapse. Golgi apparatus.
  • 蛋白家族:
    Synapsin family
  • 數據庫鏈接:

    HGNC: 11494

    OMIM: 300491

    KEGG: hsa:6853

    STRING: 9606.ENSP00000295987

    UniGene: Hs.225936



主站蜘蛛池模板: 一本热久久sm色国产| 国产97人人超碰caoprom| 中文字幕无码精品亚洲资源网| 在线观看的av免费网站| 亚洲成av人最新无码| 国产人妖xxxx做受视频| 最新精品国偷自产在线| 边吃奶边添下面好爽| 蕾丝av无码专区在线观看| 精品国产v无码大片在线观看| 极品少妇一区二区三区四区| 国产三级精品三级在线观看| 大桥久未无码吹潮在线观看 | 亚洲爆乳www无码专区| 综合自拍亚洲综合图区欧美| 中文字幕韩国三级理论| 欧美与黑人午夜性猛交久久久| 成人aa免费视频在线播放| 国产成人无码午夜福利在线直播| 久久久综合九色合综| 欧美一区二区三区成人久久片| 99精品国产99久久久久久97| 久久久精品2019免费观看| 邪恶肉肉全彩色无遮盖| 野花社区在线观看视频| 日韩精品久久久久久久电影蜜臀| 亚洲国产精品高清久久久| 国产成熟女人性满足视频| 无码人妻少妇色欲av一区二区| 97一区二区国产好的精华液| 欧美亚洲国产手机在线有码| 曰批视频免费30分钟成人| 一个人看的www免费视频在线观看| 久久精品亚洲成在人线av麻豆| av无码人妻中文字幕| 蜜桃视频无码区在线观看| 欧美gv在线观看| 国产国拍亚洲精品av| 手机在线看永久av片免费| 中日韩高清无专码区2021| 亚洲国产成av人天堂无码|