在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-SYN1 (Ser9) Antibody

  • 中文名稱:
    磷酸化-SYN1 (Ser9)兔多克隆抗體
  • 貨號:
    CSB-PA580795
  • 規(guī)格:
    ¥2454
  • 圖片:
    • Western blot analysis of extracts from Mouse Brain tissue using synapsin(Phospho-Ser9) Antibody.
    • Immunofluorescence staining of methanol-fixed Hela cells using synapsin(Phospho-Ser9) Antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SYN1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Peptide sequence around phosphorylation site of serine 9 (R-L-S(p)-D-S) derived from Human SYN1/synapsin.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
    IF 1:100-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • 基因功能參考文獻(xiàn):
    1. Authors identified the c.236 C > G/p.S79W mutation in SYN1 as causative for the non-syndromic ID of the MRX50 family. Accordingly, the in vitro characterization of S79W SynI clearly indicates that the mutation does not interfere with neurodevelopmental aspects, but perturbs spontaneous SV exocytosis, SV clustering and SV lateral mobility along axons. PMID: 28973667
    2. These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. PMID: 27515700
    3. Cerebral malaria causes pre-synaptic excitation and eventually activation of synapsin I, leading to increased neurotransmitter release. PMID: 26823711
    4. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development. PMID: 26204769
    5. The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders. PMID: 24088370
    6. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
    7. Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology. PMID: 23818987
    8. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. PMID: 23406870
    9. The histone modification marks were significantly increased in major depression and this effect was correlated with significant increases in SYN1b gene expression. PMID: 22571925
    10. The allelic frequencies of SYN1 are associated with Korean female schizophrenia. PMID: 22807112
    11. SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function. PMID: 21441247
    12. the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia. PMID: 20921223
    13. The authors propose claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion in HIV-1-infected patients. PMID: 20700059
    14. The results showed that synapsin I was significantly decreased in the stratum radiatum of CA1 subfield and the molecular layer of DG in AD patients. PMID: 14673601
    15. SYN1 nonsense mutation is the likely cause of epileptic and other phenotypes PMID: 14985377
    16. Synapsins and S100A1 interact in nerve terminals where coexpresssed; S100A1 cannot bind SV-associated synapsin I and may function as a cytoplasmic store of monomeric synapsin I; synapsin dimerization and interaction with S100A1 are mutually exclusive PMID: 15147519
    17. This study concluded that the human synapsin I gene is positively regulated by nuclear respiratory factor 1 and mediates the function of nuclear respiratory factor 1 in neurite outgrowth. PMID: 19301426

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD)
  • 亞細(xì)胞定位:
    Cell junction, synapse. Golgi apparatus.
  • 蛋白家族:
    Synapsin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11494

    OMIM: 300491

    KEGG: hsa:6853

    STRING: 9606.ENSP00000295987

    UniGene: Hs.225936



主站蜘蛛池模板: 国产成人久久精品一区二区三区| 波多野av一区二区无码| 欧洲精品免费一区二区三区| 国产丰满麻豆videossexhd| 欧美zozo另类特级| 国内一区二区三区香蕉aⅴ| 动漫无遮挡h纯肉亚洲资源大片| 亚洲人成在线影院| 久久精品中文无码资源站| 97无码精品综合| 丰满多毛少妇做爰视频爽爽和| 男女猛烈xx00免费视频试看| 精品偷自拍另类在线观看| 色综久久综合桃花网国产精品| 狠狠做五月深爱婷婷伊人| 男男啪啪激烈高潮cc漫画免费 | 亚洲精品无人区| 欧美日韩人妻精品一区二区在线| 五十路熟妇高熟无码视频| 无码少妇一区二区| 亚洲欧美色αv在线影视| 人人妻人人爽人人添夜夜欢视频| av无码av天天av天天爽| 亚洲人成电影在线播放| 久久婷婷五月综合色d啪| 亚洲人成无码网站在线观看| 亚洲精品乱码久久久久久蜜桃| 欧美 国产日韩 综合在线| 狠狠色噜噜狠狠狠狠米奇777 | 久久婷婷综合激情亚洲狠狠| 人妻.中文字幕无码| 久久精品青草社区| 狠狠色丁香久久婷婷综合图片| 亚洲欧洲成人a∨在线观看| 美女网站免费福利视频| 波多野结衣美乳人妻hd电影欧美 | 天堂资源最新在线| 国产精品国产三级国产普通话| 免费国产高清毛不卡片基地 | 无码日韩人妻精品久久蜜桃| 日本丰满熟妇videossex|