在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SYN1 Antibody

  • 中文名稱:
    SYN1兔多克隆抗體
  • 貨號(hào):
    CSB-PA168554
  • 規(guī)格:
    ¥1100
  • 圖片:
    • Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA168554(SYN1 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Brain protein 4.1 antibody; SYN 1 antibody; SYN 1a antibody; SYN 1b antibody; SYN I antibody; SYN1 antibody; SYN1_HUMAN antibody; SYN1a antibody; SYN1b antibody; Synapsin 1 antibody; Synapsin I antibody; Synapsin-1 antibody; Synapsin1 antibody; SynapsinI antibody; SYNI antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human SYN1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • 基因功能參考文獻(xiàn):
    1. Authors identified the c.236 C > G/p.S79W mutation in SYN1 as causative for the non-syndromic ID of the MRX50 family. Accordingly, the in vitro characterization of S79W SynI clearly indicates that the mutation does not interfere with neurodevelopmental aspects, but perturbs spontaneous SV exocytosis, SV clustering and SV lateral mobility along axons. PMID: 28973667
    2. These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. PMID: 27515700
    3. Cerebral malaria causes pre-synaptic excitation and eventually activation of synapsin I, leading to increased neurotransmitter release. PMID: 26823711
    4. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development. PMID: 26204769
    5. The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders. PMID: 24088370
    6. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
    7. Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology. PMID: 23818987
    8. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. PMID: 23406870
    9. The histone modification marks were significantly increased in major depression and this effect was correlated with significant increases in SYN1b gene expression. PMID: 22571925
    10. The allelic frequencies of SYN1 are associated with Korean female schizophrenia. PMID: 22807112
    11. SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function. PMID: 21441247
    12. the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia. PMID: 20921223
    13. The authors propose claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion in HIV-1-infected patients. PMID: 20700059
    14. The results showed that synapsin I was significantly decreased in the stratum radiatum of CA1 subfield and the molecular layer of DG in AD patients. PMID: 14673601
    15. SYN1 nonsense mutation is the likely cause of epileptic and other phenotypes PMID: 14985377
    16. Synapsins and S100A1 interact in nerve terminals where coexpresssed; S100A1 cannot bind SV-associated synapsin I and may function as a cytoplasmic store of monomeric synapsin I; synapsin dimerization and interaction with S100A1 are mutually exclusive PMID: 15147519
    17. This study concluded that the human synapsin I gene is positively regulated by nuclear respiratory factor 1 and mediates the function of nuclear respiratory factor 1 in neurite outgrowth. PMID: 19301426

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD)
  • 亞細(xì)胞定位:
    Cell junction, synapse. Golgi apparatus.
  • 蛋白家族:
    Synapsin family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 11494

    OMIM: 300491

    KEGG: hsa:6853

    STRING: 9606.ENSP00000295987

    UniGene: Hs.225936



主站蜘蛛池模板: 国产亚洲精品精品精品| 狠狠色噜噜狠狠狠狠五月婷| 亚洲国产丝袜精品一区| 色妞ww精品视频7777| 无罩大乳的熟妇正在播放| 无码内射中文字幕岛国片 | 久久精品国产精品亚洲蜜月| 国产又大又硬又粗| 国产毛a片啊久久久久久保和丸| 日本www一道久久久免费| 鲁一鲁av2019在线| 亚洲精品久久久久国产| 亚洲成av人片久久| 国产成人精品午夜福利在线播放 | 午夜毛片不卡高清免费看| 精品熟女日韩中文十区| 男人用嘴添女人私密视频| 国产成在线观看免费视频| 最新在线精品国自产拍福利| 天天躁日日躁狠狠躁av| 国产99视频精品免费专区| 综合欧美亚洲日本一区| 国产精品久久久爽爽爽麻豆色哟哟 | 青青草国产精品日韩欧美| 十八禁午夜福利免费网站| 国精产品一区一区三区免费视频 | 国产aⅴ爽av久久久久久| 亚洲精品久久久av无码专区| 国产人久久人人人人爽| 与子敌伦刺激对白播放的优点 | 无码制服丝袜人妻在线视频精品| 亚洲精品一区二区三区中文字幕 | 无码人妻丝袜在线视频红杏| 肥臀熟女一区二区三区| 国产免国产免‘费| 52熟女露脸国语对白视频| 国模雨珍浓密毛大尺度150p| 国产亚洲精品美女久久久久| 久久五月丁香激情综合| 欧美40老熟妇色xxxxx| 国产农村熟妇videos|