在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLU7 Antibody

  • 中文名稱(chēng):
    SLU7兔多克隆抗體
  • 貨號(hào):
    CSB-PA006636
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of SH-SY5Y cells using SLU7 Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    9G8 antibody; hSlu7 antibody; MGC9280 antibody; Pre mRNA splicing factor SLU7 antibody; Pre-mRNA-splicing factor slu7 antibody; SLU 7 antibody; slu7 antibody; SLU7 splicing factor homolog (S. cerevisiae) antibody; SLU7 splicing factor homolog antibody; SLU7_HUMAN antibody; splicing factor antibody; Step II splicing factor SLU7 antibody; Zinc knuckle motif containing antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human SLU7.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
  • 基因功能參考文獻(xiàn):
    1. these findings indicate that SLU7 is co-opted by hepatocellular carcinoma (HCC) cells and other tumor cell types to maintain survival, and identify this splicing regulator as a new determinant for the expression of the oncogenic miR-17-92 cluster. This novel mechanism may be exploited for the development of antitumoral strategies in cancers displaying such SLU7-miR-17-92 crosstalk PMID: 26804174
    2. SLU7 knockdown in liver cells resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern. PMID: 24865429
    3. These observations together point to an altered recruitment and dependence on SLU7, suggesting its role in facilitating transitions that promote catalysis, and highlight the diversity in spliceosome assembly. PMID: 23754748
    4. RBM22 and hSlu7 differ significantly in their subcellular distributions under stress conditions, and RBM22 enhances the cytoplasmic translocation of hSlu7 under stress. PMID: 21122810
    5. The zinc-knuckle motif of hSlu7 determines the cellular localization of the protein through a nucleocytoplasmic-sensitive shuttling balance. PMID: 15181151
    6. hSlu7 has a broad effect on alternative splicing PMID: 15728250
    7. Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing PMID: 17804646

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Nucleus speckle. Cytoplasm.
  • 蛋白家族:
    SLU7 family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 16939

    OMIM: 605974

    KEGG: hsa:10569

    STRING: 9606.ENSP00000297151

    UniGene: Hs.435342



主站蜘蛛池模板: 18禁裸乳无遮挡啪啪无码免费| 国产精品亚洲专区无码老司国| 太深太粗太爽太猛了视频免费观看| 国产又色又爽又刺激在线观看| 大乳丰满人妻中文字幕日本| 男女吃奶做爰猛烈紧视频| 亚洲mv国产mv在线mv综合试看| a毛片免费全部播放| 熟女乱亚洲图| 巨爆乳中文字幕爆乳区| 日本在线高清不卡免费播放| 久久中文字幕无码a片不卡古代| 国产精品日本亚洲777| 久久成人a毛片免费观看网站| 国产色婷婷五月精品综合在线| 丰满少妇高潮惨叫久久久一| 秋霞午夜鲁丝片午夜精品| 久久精品一区二区免费播放| 熟妇女人妻丰满少妇中文字幕| 乱人伦xxxx国语对白| 中国人妻被两个老外三p| 日本熟妇厨房bbw| 国产精品99精品久久免费| 中文字幕无线码一区二区| 亚洲另类成人小说综合网| 男女一边摸一边做爽爽的免费阅读| 真实的国产乱xxxx| 老子午夜精品无码| 女人扒下裤让男人桶到爽| 欧美真人性做爰一二区| 97香蕉碰碰人妻国产欧美| 欧美激欧美啪啪片免费看| 色综合欧美五月俺也去| 久久久成人毛片无码| 强睡邻居人妻中文字幕| 久久精品亚洲精品国产色婷| 国产欧美日韩精品专区| 欧美性色19p| 无码h片在线观看网站| 四虎永久在线精品免费观看视频| 131美女爱做视频国产福利|