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RPL3 Antibody

  • 中文名稱:
    RPL3兔多克隆抗體
  • 貨號:
    CSB-PA02385A0Rb
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA02385A0Rb at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RPL3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RPL3
  • 別名:
    60S ribosomal protein L3 antibody; HIV-1 TAR RNA-binding protein B antibody; HIV1 TAR RNA binding protein B antibody; MGC103388 antibody; MGC104284 antibody; MGC72934 antibody; Ribosomal protein L3 antibody; Ribosomal protein L3, isoform a antibody; RL3_HUMAN antibody; rpl3 antibody; TARBP B antibody; TARBP-B antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human 60S ribosomal protein L3 protein (2-247AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,RPL3 Antibody (CSB-PA02385A0Rb),的標記方式是Non-conjugated。對于RPL3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA02385B0Rb RPL3 Antibody, HRP conjugated ELISA
    FITC CSB-PA02385C0Rb RPL3 Antibody, FITC conjugated
    Biotin CSB-PA02385D0Rb RPL3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
  • 基因功能參考文獻:
    1. The sensitivity of p53 null colon cancer cells to 5-FU can be enhanced using proapoptotic rpL3 gene. PMID: 27835895
    2. nucleolar stress induced by 5-fluorouracil in colon cancer cells devoid of p53 leads to the activation of ribosomal protein L3 as proapoptotic factor PMID: 27385096
    3. We found that uL3 down-regulation correlates positively with multidrug resistance. Restoration of the uL3 protein level re-sensitized the resistant cells to the drug by regulating the reactive oxygen species (ROS) levels, glutathione content, glutamate release, and cystine uptake. PMID: 28273808
    4. rpL3 participates in the cell response to chemotherapy acting as a critical regulator of cell cycle, apoptosis and DNA repair, by modulating p21 expression PMID: 25473889
    5. The rpL3 is able to modulate the protein amounts of p21 through a novel pathway independent from p53 involving Sp1 and NPM. PMID: 23255119
    6. NPM and KHSRP are two newly identified proteins involved in the regulation of rpL3 gene expression via alternative pre-mRNA splicing. PMID: 21705779
    7. working model in which rpL3 recruits hnRNP H1 and, through cooperation with other splicing factors, promotes selection of the alternative splice site PMID: 20100605

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  • 亞細胞定位:
    Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族:
    Universal ribosomal protein uL3 family
  • 數據庫鏈接:

    HGNC: 10332

    OMIM: 604163

    KEGG: hsa:6122

    STRING: 9606.ENSP00000346001

    UniGene: Hs.119598



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