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  4. RPL3 Antibody, Biotin conjugated

RPL3 Antibody, Biotin conjugated

  • 中文名稱：
    RPL3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA02385D0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RPL3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RPL3
  • 別名：
    60S ribosomal protein L3 antibody; HIV-1 TAR RNA-binding protein B antibody; HIV1 TAR RNA binding protein B antibody; MGC103388 antibody; MGC104284 antibody; MGC72934 antibody; Ribosomal protein L3 antibody; Ribosomal protein L3, isoform a antibody; RL3_HUMAN antibody; rpl3 antibody; TARBP B antibody; TARBP-B antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human 60S ribosomal protein L3 protein (2-247AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
  • 基因功能參考文獻：
    1. The sensitivity of p53 null colon cancer cells to 5-FU can be enhanced using proapoptotic rpL3 gene. PMID: 27835895
    2. nucleolar stress induced by 5-fluorouracil in colon cancer cells devoid of p53 leads to the activation of ribosomal protein L3 as proapoptotic factor PMID: 27385096
    3. We found that uL3 down-regulation correlates positively with multidrug resistance. Restoration of the uL3 protein level re-sensitized the resistant cells to the drug by regulating the reactive oxygen species (ROS) levels, glutathione content, glutamate release, and cystine uptake. PMID: 28273808
    4. rpL3 participates in the cell response to chemotherapy acting as a critical regulator of cell cycle, apoptosis and DNA repair, by modulating p21 expression PMID: 25473889
    5. The rpL3 is able to modulate the protein amounts of p21 through a novel pathway independent from p53 involving Sp1 and NPM. PMID: 23255119
    6. NPM and KHSRP are two newly identified proteins involved in the regulation of rpL3 gene expression via alternative pre-mRNA splicing. PMID: 21705779
    7. working model in which rpL3 recruits hnRNP H1 and, through cooperation with other splicing factors, promotes selection of the alternative splice site PMID: 20100605

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  • 亞細胞定位：
    Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    Universal ribosomal protein uL3 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10332

    OMIM: 604163

    KEGG: hsa:6122

    STRING: 9606.ENSP00000346001

    UniGene: Hs.119598



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