在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF126 Antibody

RNF126 Antibody

  • 中文名稱：
    RNF126兔多克隆抗體
  • 貨號：
    CSB-PA059841
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA059841(RNF126 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA059841(RNF126 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, K562 cells, Primary antibody: CSB-PA059841(RNF126 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    RNF126
  • 別名：
    E3 ubiquitin-protein ligase RNF126 antibody; FLJ20552 antibody; MGC1022 antibody; MGC14317 antibody; RING finger protein 126 antibody; RN126_HUMAN antibody; RNF 126 antibody; RNF126 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human RNF126
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA.
  • 基因功能參考文獻：
    1. Studies present the solution structure of the RNF126_NZF (N-terminal zinc finger domain) as well as the structure of RNF126_NZF/BAG6_UBL complex and characterize the interaction of RNF126 with the UBL domains from both BAG6 and UBL4A from the BAG6 sortase complex. PMID: 27193484
    2. RNF126 depletion results in frataxin accumulation in cells derived from FRDA patients. PMID: 28228265
    3. These data suggested that RNF126 might be related to the progression of tongue cancer through regulating AKT signaling pathway. PMID: 27227488
    4. RNF126 is a novel regulator of NHEJ that promotes completion of DNA repair by ubiquitylating Ku80 and releasing Ku70/80 from damaged DNA. PMID: 27895153
    5. this results suggest a novel role of RNF126 in promoting Homologous recombination-mediated repair through positive regulation on BRCA1 expression by direct interaction with E2F1. PMID: 26234677
    6. RNF126 is recruited to the N-terminal Ubl domain of Bag6 and preferentially ubiquitinates juxtahydrophobic lysine residues on Bag6-associated clients. PMID: 24981174
    7. The ubiquitin ligase RNF126 has a role in the retrograde sorting of the CI-MPR. PMID: 24275455
    8. RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors. PMID: 23418353
    9. identify a unique cofactor, RING finger protein 126 (RNF126), verify its interaction by traditional techniques, and show that it has functional consequences as RNF126 is able to ubiquitylate activation-induced cytidine deaminase PMID: 23277564
    10. These findings suggest that RNF126 promotes cancer cell proliferation by targeting p21 for ubiquitin-mediated degradation PMID: 23026136

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Highly expressed in liver and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21151

    OMIM: 615177

    KEGG: hsa:55658

    STRING: 9606.ENSP00000292363

    UniGene: Hs.69554



主站蜘蛛池模板： 精品久久久久中文字幕app| 久久亚洲精品情侣| 亚洲乱码日产精品bd| 女人国产香蕉久久精品| 男人的天堂在线视频 | 人妻av无码专区| 亚洲日韩一区二区| 无码成人aaaaa毛片| 东北老头嫖妓猛对白精彩| 人妻 偷拍 无码 中文字幕| 欧美18videosex性欧美黑吊| 欧美老熟妇xb水多毛多| 日本成本人片视频免费| 国产精品一区在线蜜臀| 欧美日韩不卡合集视频| 色综合欧美在线视频区| 久久国产精品无码hdav| 久久久精品456亚洲影院| 欧美毛多水多肥妇| 国内精品久久久久久中文字幕| 高清破外女出血av毛片| 无码精品人妻一区二区三区av| av人摸人人人澡人人超碰妓女| 亚洲成在人线av| 新普新京亚洲欧美日韩国产| 牲高潮99爽久久久久777| 成av人片一区二区三区久久| 午夜无码乱码在线观看| 国产成人精品永久免费视频| 男女啪啪高潮无遮挡免费| 精品深夜av无码一区二区| 国产麻豆精品av在线观看| 青娱国产区在线| 久久综合九色综合97欧美| 无码一区二区三区av免费| 曰本一道本久久88不卡| 欧美做受又硬又粗又大视频| 女人大荫蒂毛茸茸视频| 国产黄网永久免费视频大全| 天天躁夜夜躁狠狠综合| 农民人伦一区二区三区|