在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human RING finger protein 126 (RNF126)

  • 中文名稱:
    人RNF126重組蛋白
  • 貨號:
    CSB-YP019828HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RNF126重組蛋白
  • 貨號:
    CSB-EP019828HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RNF126重組蛋白
  • 貨號:
    CSB-BP019828HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RNF126重組蛋白
  • 貨號:
    CSB-MP019828HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RNF126
  • Uniprot No.:
  • 別名:
    E3 ubiquitin-protein ligase RNF126; FLJ20552; MGC1022; MGC14317; RING finger protein 126; RN126_HUMAN; RNF 126; RNF126
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-311
  • 氨基酸序列
    AEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA.
  • 基因功能參考文獻:
    1. Studies present the solution structure of the RNF126_NZF (N-terminal zinc finger domain) as well as the structure of RNF126_NZF/BAG6_UBL complex and characterize the interaction of RNF126 with the UBL domains from both BAG6 and UBL4A from the BAG6 sortase complex. PMID: 27193484
    2. RNF126 depletion results in frataxin accumulation in cells derived from FRDA patients. PMID: 28228265
    3. These data suggested that RNF126 might be related to the progression of tongue cancer through regulating AKT signaling pathway. PMID: 27227488
    4. RNF126 is a novel regulator of NHEJ that promotes completion of DNA repair by ubiquitylating Ku80 and releasing Ku70/80 from damaged DNA. PMID: 27895153
    5. this results suggest a novel role of RNF126 in promoting Homologous recombination-mediated repair through positive regulation on BRCA1 expression by direct interaction with E2F1. PMID: 26234677
    6. RNF126 is recruited to the N-terminal Ubl domain of Bag6 and preferentially ubiquitinates juxtahydrophobic lysine residues on Bag6-associated clients. PMID: 24981174
    7. The ubiquitin ligase RNF126 has a role in the retrograde sorting of the CI-MPR. PMID: 24275455
    8. RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors. PMID: 23418353
    9. identify a unique cofactor, RING finger protein 126 (RNF126), verify its interaction by traditional techniques, and show that it has functional consequences as RNF126 is able to ubiquitylate activation-induced cytidine deaminase PMID: 23277564
    10. These findings suggest that RNF126 promotes cancer cell proliferation by targeting p21 for ubiquitin-mediated degradation PMID: 23026136

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 組織特異性:
    Highly expressed in liver and testis.
  • 數據庫鏈接:

    HGNC: 21151

    OMIM: 615177

    KEGG: hsa:55658

    STRING: 9606.ENSP00000292363

    UniGene: Hs.69554



主站蜘蛛池模板: 色悠久久久久综合网国产 | 成人国产一区二区三区精品不卡| 国产剧情无码播放在线看| 亚洲加勒比无码一区二区| 麻豆果冻传媒精品| 中文字幕v亚洲日本在线| 国产区在线观看成人精品| 国产一区二区三区不卡av| 熟妇人妻中文av无码| 无套内谢少妇毛片aaaa片免费 | 综合无码成人aⅴ视频在线观看| 欧美极品色午夜在线视频| 最近中文av字幕在线中文| 樱花草在线社区www日本影院| av无码中文字幕不卡一区二区三区| 亚洲成av人片在线观看下载| 性欧美暴力猛交69hd| 亚洲国产欧美在线成人| 夜夜添无码试看一区二区三区| 鲁鲁狠狠狠7777一区二区| 亚洲精品国产精华液| 国产免费人成视频尤勿视频| 成人看片黄a免费看| 欧美大荫蒂毛茸茸视频| aaaaa少妇高潮大片| 狠狠色噜噜狠狠狠888777米奇| av无码久久久久不卡网站蜜桃| 人妻 日韩 欧美 综合 制服| 国产偷伦视频片免费视频| 欧美性猛少妇xxxxx免费| 国产精品国产三级国产av主播| 人妻aⅴ中文字幕| 久久99精品久久久久久清纯| 国产性天天综合网| 婷婷四房色播| 国产三级韩国三级日产三级| 亚洲综合色视频在线观看| 国产在线 | 中文| 黑人巨大无码中文字幕无码| 免费国产在线精品一区二区三区| 亚洲啪av永久无码精品放毛片|