在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF126 Antibody, FITC conjugated

RNF126 Antibody, FITC conjugated

  • 中文名稱(chēng)：
    RNF126兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA019828LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) RNF126 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF126
  • 別名：
    E3 ubiquitin-protein ligase RNF126 antibody; FLJ20552 antibody; MGC1022 antibody; MGC14317 antibody; RING finger protein 126 antibody; RN126_HUMAN antibody; RNF 126 antibody; RNF126 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF126 protein (39-225AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA.
  • 基因功能參考文獻(xiàn)：
    1. Studies present the solution structure of the RNF126_NZF (N-terminal zinc finger domain) as well as the structure of RNF126_NZF/BAG6_UBL complex and characterize the interaction of RNF126 with the UBL domains from both BAG6 and UBL4A from the BAG6 sortase complex. PMID: 27193484
    2. RNF126 depletion results in frataxin accumulation in cells derived from FRDA patients. PMID: 28228265
    3. These data suggested that RNF126 might be related to the progression of tongue cancer through regulating AKT signaling pathway. PMID: 27227488
    4. RNF126 is a novel regulator of NHEJ that promotes completion of DNA repair by ubiquitylating Ku80 and releasing Ku70/80 from damaged DNA. PMID: 27895153
    5. this results suggest a novel role of RNF126 in promoting Homologous recombination-mediated repair through positive regulation on BRCA1 expression by direct interaction with E2F1. PMID: 26234677
    6. RNF126 is recruited to the N-terminal Ubl domain of Bag6 and preferentially ubiquitinates juxtahydrophobic lysine residues on Bag6-associated clients. PMID: 24981174
    7. The ubiquitin ligase RNF126 has a role in the retrograde sorting of the CI-MPR. PMID: 24275455
    8. RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors. PMID: 23418353
    9. identify a unique cofactor, RING finger protein 126 (RNF126), verify its interaction by traditional techniques, and show that it has functional consequences as RNF126 is able to ubiquitylate activation-induced cytidine deaminase PMID: 23277564
    10. These findings suggest that RNF126 promotes cancer cell proliferation by targeting p21 for ubiquitin-mediated degradation PMID: 23026136

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Highly expressed in liver and testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21151

    OMIM: 615177

    KEGG: hsa:55658

    STRING: 9606.ENSP00000292363

    UniGene: Hs.69554



主站蜘蛛池模板： 婷婷久久综合九色综合绿巨人| 中文字幕无码乱人伦| 特级无码毛片免费视频| 在线观看一区二区三区国产免费| 77se77亚洲欧美在线| 亚洲自偷自拍另类11p| 日出水了特别黄的视频| 国内大量揄拍人妻精品視頻| 国产亚洲精品合集久久久久| 人妻丰满熟妇ⅴ无码区a片| 美女视频黄是免费| 日韩欧美中文字幕在线三区| 日产乱码一二三区别免费麻豆| 人妻熟女一区二区三区app下载 | av无码精品一区二区三区宅噜噜 | 亚洲综合无码一区二区三区| 久久久久国产精品人妻aⅴ毛片 | 国产性生交xxxxx免费| 蜜臀av综合网| 衣服被扒开强摸双乳18禁网站| 熟妇人妻一区二区三区四区 | 精品国产av 无码一区二区三区 | 欧美精品一国产成人综合久久| 精品国产一区二区三区香蕉| 国产成人一区二区三区在线观看 | 色偷偷亚洲男人本色| 熟妇人妻午夜寂寞影院| 国产成人18黄网站在线观看| 大地资源在线观看官网第三页| 亚洲国产精品无码久久久久高潮| 久久精品国产首页027007| 亚洲色无码中文字幕在线| 无码av一区二区三区无码| 欧美大黑帍在线播放| 亚洲国产精品成人精品无码区| 国产在线视频www色| 日韩国产丝袜人妻一二区| 天干天干夜啦天干天干国产| 丰满少妇呻吟高潮经历| 国产在线观看码高清视频| 国产精品亚洲精品一区二区|