在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF126 Antibody, HRP conjugated

RNF126 Antibody, HRP conjugated

  • 中文名稱：
    RNF126兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA019828LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RNF126 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF126
  • 別名：
    E3 ubiquitin-protein ligase RNF126 antibody; FLJ20552 antibody; MGC1022 antibody; MGC14317 antibody; RING finger protein 126 antibody; RN126_HUMAN antibody; RNF 126 antibody; RNF126 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF126 protein (39-225AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA.
  • 基因功能參考文獻(xiàn)：
    1. Studies present the solution structure of the RNF126_NZF (N-terminal zinc finger domain) as well as the structure of RNF126_NZF/BAG6_UBL complex and characterize the interaction of RNF126 with the UBL domains from both BAG6 and UBL4A from the BAG6 sortase complex. PMID: 27193484
    2. RNF126 depletion results in frataxin accumulation in cells derived from FRDA patients. PMID: 28228265
    3. These data suggested that RNF126 might be related to the progression of tongue cancer through regulating AKT signaling pathway. PMID: 27227488
    4. RNF126 is a novel regulator of NHEJ that promotes completion of DNA repair by ubiquitylating Ku80 and releasing Ku70/80 from damaged DNA. PMID: 27895153
    5. this results suggest a novel role of RNF126 in promoting Homologous recombination-mediated repair through positive regulation on BRCA1 expression by direct interaction with E2F1. PMID: 26234677
    6. RNF126 is recruited to the N-terminal Ubl domain of Bag6 and preferentially ubiquitinates juxtahydrophobic lysine residues on Bag6-associated clients. PMID: 24981174
    7. The ubiquitin ligase RNF126 has a role in the retrograde sorting of the CI-MPR. PMID: 24275455
    8. RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors. PMID: 23418353
    9. identify a unique cofactor, RING finger protein 126 (RNF126), verify its interaction by traditional techniques, and show that it has functional consequences as RNF126 is able to ubiquitylate activation-induced cytidine deaminase PMID: 23277564
    10. These findings suggest that RNF126 promotes cancer cell proliferation by targeting p21 for ubiquitin-mediated degradation PMID: 23026136

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Highly expressed in liver and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21151

    OMIM: 615177

    KEGG: hsa:55658

    STRING: 9606.ENSP00000292363

    UniGene: Hs.69554



主站蜘蛛池模板： 日韩精品无码成人专区| 婷婷五月综合丁香在线| 亚洲日韩欧美国产另类综合| 亚洲精品四区麻豆文化传媒| 国产午夜福利在线观看视频_| 天天鲁在视频在线观看| 人人摸人人搞人人透| 人人妻人人玩人人澡人人爽| 美女扒开屁股让男人桶| 亚洲性夜夜天天天| 偷窥 亚洲 另类 图片 熟女| 欧美伊人色综合久久天天| 欧洲成人午夜精品无码区久久| 99视频偷窥在线精品国自产拍| 人妻少妇heyzo无码专区| 超碰97人人做人人爱亚洲| 制服丝袜有码中文字幕在线| 伊人中文字幕无码专区| 欧洲精品免费一区二区三区| 全部孕妇毛片丰满孕妇孕交 | 高清偷自拍第1页| 国产成人午夜福利在线观看| 久久久久久99av无码免费网站| 亚洲va中文在线播放| 亚洲色爱图小说专区| 日韩大片高清播放器| 欧美巨波霸乳影院| 国产av老师丝袜美腿丝袜| 日韩免费无砖专区2020狼| 国产真人做爰视频免费| 国产露脸无套对白在线播放| 香蕉久久久久久久av网站| 国产成人精品久久久久精品日日 | 国产美女久久久亚洲综合| 久久久噜噜噜久久| 亚洲熟妇无码乱子av电影| 久久久青草青草免费看| 天堂www中文资源| 国产午夜亚洲精品国产成人小说 | 白又丰满大屁股bbbbb| 永久免费的av片在线电影网|