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  4. Phospho-MAPK6 (S189) Antibody

Phospho-MAPK6 (S189) Antibody

  • 中文名稱：
    磷酸化-MAPK6 (S189)兔多克隆抗體
  • 貨號：
    CSB-PA030292
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ERK-3 antibody; ERK3 antibody; Extracellular signal regulated kinase 3 antibody; Extracellular signal regulated kinase p97 antibody; Extracellular signal-regulated kinase 3 antibody; HsT17250 antibody; MAP kinase 6 antibody; MAP kinase isoform p97 antibody; MAPK 6 antibody; MAPK6 antibody; Mitogen activated protein kinase 6 antibody; Mitogen-activated protein kinase 6 antibody; MK06_HUMAN antibody; p97 MAPK antibody; p97-MAPK antibody; PRKM6 antibody; Protein kinase mitogen activated 5 antibody; Protein kinase mitogen activated 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human ERK 3 around the phosphorylation site of S189.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
  • 基因功能參考文獻：
    1. Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK/p38 MAPK-ERK3/mTORC1 pathways. ERK3 is a newfound potential prognostic predictor and a tumor suppressor in ICC. PMID: 28241849
    2. Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells' DNA damage response and chemoresistance to Top2 inhibitors. PMID: 26701725
    3. MAPK6 could rescue the cell growth induced by miR499a and HBV PMID: 25340781
    4. ERK3 regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3/SP-1-mediated VEGFR2 expression. PMID: 24585635
    5. These findings further expand distinct roles of cyclin D3 and suggest the potential activity of ERK3 in cell proliferation. PMID: 16360641
    6. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225
    7. identify the Erk3 protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling. PMID: 21317288
    8. A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation. PMID: 22505454
    9. ERK3 biological activity is regulated by its cellular abundance through the control of protein stability PMID: 12808096
    10. Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 but not that of substrates ubiquitinated on internal lysine residues. PMID: 15226418
    11. Extracellular signal-regulated kinase-3 (ERK3/MAPK6) is highly expressed in response to BRAF signaling. PMID: 16964379

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
  • 組織特異性：
    Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6879

    OMIM: 602904

    KEGG: hsa:5597

    STRING: 9606.ENSP00000261845

    UniGene: Hs.411847



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