在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAPK6 Antibody

  • 中文名稱:
    MAPK6兔多克隆抗體
  • 貨號:
    CSB-PA073951
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from K562 cells, using p97 MAPK antibody.
    • Immunofluorescence analysis of MCF-7 cells, using p97 MAPK antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MAPK6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human p97 MAPK.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
  • 基因功能參考文獻:
    1. Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK/p38 MAPK-ERK3/mTORC1 pathways. ERK3 is a newfound potential prognostic predictor and a tumor suppressor in ICC. PMID: 28241849
    2. Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells' DNA damage response and chemoresistance to Top2 inhibitors. PMID: 26701725
    3. MAPK6 could rescue the cell growth induced by miR499a and HBV PMID: 25340781
    4. ERK3 regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3/SP-1-mediated VEGFR2 expression. PMID: 24585635
    5. These findings further expand distinct roles of cyclin D3 and suggest the potential activity of ERK3 in cell proliferation. PMID: 16360641
    6. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225
    7. identify the Erk3 protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling. PMID: 21317288
    8. A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation. PMID: 22505454
    9. ERK3 biological activity is regulated by its cellular abundance through the control of protein stability PMID: 12808096
    10. Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 but not that of substrates ubiquitinated on internal lysine residues. PMID: 15226418
    11. Extracellular signal-regulated kinase-3 (ERK3/MAPK6) is highly expressed in response to BRAF signaling. PMID: 16964379

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
  • 組織特異性:
    Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
  • 數據庫鏈接:

    HGNC: 6879

    OMIM: 602904

    KEGG: hsa:5597

    STRING: 9606.ENSP00000261845

    UniGene: Hs.411847



主站蜘蛛池模板: 日韩一区二区三区射精| 成 人 免费观看网站| 少妇高潮惨叫久久久久久| 国产亚洲精品久久久久久小说| 日韩加勒比一本无码精品| 又硬又粗进去好爽免费| 亚洲人成网7777777国产| 国产精品天干天干综合网| 国产精品人成视频国模| 超薄丝袜足j好爽在线观看| 国产精品无码一本二本三本色| 特级毛片爽www免费版| 国产精品美女乱子伦高| 第一亚洲中文久久精品无码| 亚洲性猛交xxxx| 国产女同疯狂作爱系列| 久久综合一色综合久久小蛇 | a级大胆欧美人体大胆666| 精品人妻无码区二区三区| 免费体验区试看120秒| 亚洲女教师丝祙在线播放| 国产成人无码a区在线观看视频app| 国产精品v片在线观看不卡| 精品www日韩熟女人妻| 99久热re在线精品视频| 青青草av国产精品| 女被男啪到哭的视频网站| 国产精品老熟女露脸视频| 国产日韩av一区二区三区五区| 亚洲熟女乱色一区二区三区| 免费无码av一区二区| 国产高清在线精品一区小说| 在线观看成人无码中文av天堂| 精品国产a∨无码一区二区三区| www国产亚洲精品久久| 高清无码爆乳潮喷在线观看| 特级精品毛片免费观看| 又色又爽又黄的gif动态图| 激烈的性高湖波多野结衣 | 老司机久久99久久精品播放| 亚洲中国最大av网站|