在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAPK6 Antibody, HRP conjugated

MAPK6 Antibody, HRP conjugated

  • 中文名稱：
    MAPK6兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA013458LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MAPK6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ERK-3 antibody; ERK3 antibody; Extracellular signal regulated kinase 3 antibody; Extracellular signal regulated kinase p97 antibody; Extracellular signal-regulated kinase 3 antibody; HsT17250 antibody; MAP kinase 6 antibody; MAP kinase isoform p97 antibody; MAPK 6 antibody; MAPK6 antibody; Mitogen activated protein kinase 6 antibody; Mitogen-activated protein kinase 6 antibody; MK06_HUMAN antibody; p97 MAPK antibody; p97-MAPK antibody; PRKM6 antibody; Protein kinase mitogen activated 5 antibody; Protein kinase mitogen activated 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mitogen-activated protein kinase 6 protein (383-712AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
  • 基因功能參考文獻：
    1. Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK/p38 MAPK-ERK3/mTORC1 pathways. ERK3 is a newfound potential prognostic predictor and a tumor suppressor in ICC. PMID: 28241849
    2. Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells' DNA damage response and chemoresistance to Top2 inhibitors. PMID: 26701725
    3. MAPK6 could rescue the cell growth induced by miR499a and HBV PMID: 25340781
    4. ERK3 regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3/SP-1-mediated VEGFR2 expression. PMID: 24585635
    5. These findings further expand distinct roles of cyclin D3 and suggest the potential activity of ERK3 in cell proliferation. PMID: 16360641
    6. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225
    7. identify the Erk3 protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling. PMID: 21317288
    8. A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation. PMID: 22505454
    9. ERK3 biological activity is regulated by its cellular abundance through the control of protein stability PMID: 12808096
    10. Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 but not that of substrates ubiquitinated on internal lysine residues. PMID: 15226418
    11. Extracellular signal-regulated kinase-3 (ERK3/MAPK6) is highly expressed in response to BRAF signaling. PMID: 16964379

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
  • 組織特異性：
    Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
  • 數據庫鏈接：

    HGNC: 6879

    OMIM: 602904

    KEGG: hsa:5597

    STRING: 9606.ENSP00000261845

    UniGene: Hs.411847



主站蜘蛛池模板： 在线视频 亚太 国产 欧美 一区二区 | 久久国产劲暴∨内射新川| 成人亚洲a片v一区二区三区蜜臀 | 婷婷久久综合九色综合| 永久免费无码成人网站| 亚洲—本道 在线无码av发| 好吊射视频988gaocom| 大屁股熟女一区二区三区| 亚洲成av人无码综合在线观看| 粗了大了 整进去好爽视频| 久久97国产超碰青草| 午夜福利午夜福利1000| 三级全黄的视频在线观看| 无码人妻aⅴ一区二区三区69岛 | 18禁黄污吃奶免费看网站| 欧美性xxxxx极品少妇| 一本一本久久a久久综合精品蜜桃 国产精品人妻久久毛片高清无卡 成视频年人黄网站视频福利 | 热re99久久6国产精品免费| 中文字幕乱偷无码av先锋| 亚洲国产精品久久久久爰色欲| 99尹人香蕉国产免费天天| 欧美大香线蕉线伊人久久| 无码精品人妻一区二区三区湄公河| 狠狠97人人婷婷五月| 国产麻豆精品久久一二三| 婷婷俺也去俺也去官网| 国产亚洲人成网站在线观看| 国产精品成人一区二区三区| 人人妻人人狠人人爽| 玩弄漂亮少妇高潮白浆| 国产精品一区二区手机在线观看| 欧美中日韩免费观看网站| 国产免费又爽又色又粗视频| 国产色产综合色产在线视频| 免费人成网站视频在线观看国内| 久久不见久久见www电影免费| 亚洲精品一区国产精品| 国产 在线 | 日韩| 熟妇丰满大屁股在线播放| 国产精品久久久久久久久鸭| 成人午夜视频精品一区|