在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAPK6 Antibody

MAPK6 Antibody

  • 中文名稱：
    MAPK6兔多克隆抗體
  • 貨號：
    CSB-PA013458LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA013458LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MAPK6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ERK-3 antibody; ERK3 antibody; Extracellular signal regulated kinase 3 antibody; Extracellular signal regulated kinase p97 antibody; Extracellular signal-regulated kinase 3 antibody; HsT17250 antibody; MAP kinase 6 antibody; MAP kinase isoform p97 antibody; MAPK 6 antibody; MAPK6 antibody; Mitogen activated protein kinase 6 antibody; Mitogen-activated protein kinase 6 antibody; MK06_HUMAN antibody; p97 MAPK antibody; p97-MAPK antibody; PRKM6 antibody; Protein kinase mitogen activated 5 antibody; Protein kinase mitogen activated 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mitogen-activated protein kinase 6 protein (383-712AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MAPK6 Antibody (CSB-PA013458LA01HU)，的標記方式是Non-conjugated。對于MAPK6 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA013458LB01HU MAPK6 Antibody, HRP conjugated ELISA
    FITC CSB-PA013458LC01HU MAPK6 Antibody, FITC conjugated
    Biotin CSB-PA013458LD01HU MAPK6 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
  • 基因功能參考文獻：
    1. Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK/p38 MAPK-ERK3/mTORC1 pathways. ERK3 is a newfound potential prognostic predictor and a tumor suppressor in ICC. PMID: 28241849
    2. Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells' DNA damage response and chemoresistance to Top2 inhibitors. PMID: 26701725
    3. MAPK6 could rescue the cell growth induced by miR499a and HBV PMID: 25340781
    4. ERK3 regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3/SP-1-mediated VEGFR2 expression. PMID: 24585635
    5. These findings further expand distinct roles of cyclin D3 and suggest the potential activity of ERK3 in cell proliferation. PMID: 16360641
    6. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225
    7. identify the Erk3 protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling. PMID: 21317288
    8. A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation. PMID: 22505454
    9. ERK3 biological activity is regulated by its cellular abundance through the control of protein stability PMID: 12808096
    10. Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 but not that of substrates ubiquitinated on internal lysine residues. PMID: 15226418
    11. Extracellular signal-regulated kinase-3 (ERK3/MAPK6) is highly expressed in response to BRAF signaling. PMID: 16964379

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
  • 組織特異性：
    Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
  • 數據庫鏈接：

    HGNC: 6879

    OMIM: 602904

    KEGG: hsa:5597

    STRING: 9606.ENSP00000261845

    UniGene: Hs.411847



主站蜘蛛池模板： 色综合天天视频在线观看| 国产精品无码av在线播放| 好吊色欧美一区二区三区四区| 天堂www中文在线资源| 在线看免费无码av天堂| 国产suv精品一区二区6 | 欧美尺码专线欧洲b1b1| 老师黑色丝袜被躁翻了av| 中文成人无码精品久久久动漫| 中文天堂最新版资源www官网 | 亚洲人成电影在线播放| 狠狠综合亚洲综合亚洲色| 精品国产你懂的在线观看| 人人爽久久久噜人人看| 精品国产日韩亚洲一区| 欧美精品一区二区黄a片| 久久久久成人精品无码| 欧美黑人又粗又大高潮喷水| 9420免费高清在线观看视频| 无码h黄肉动漫在线观看| 无码日日模日日碰夜夜爽| 久久精品人妻无码专区| 久久婷婷五月综合97色| 成人h视频在线观看| 亚洲精品天天影视综合网| 日本在线a一区视频| 韩国国内大量揄拍精品视频| 精品偷拍一区二区三区在线看| 日本饥渴人妻欲求不满| 日本真人做爰免费的视频| 日韩国产亚洲欧美中国v| 男人的天堂免费一区二区视频| 欧美黑人激情性久久| 99久久亚洲精品无码毛片 | 日日拍夜夜嗷嗷叫国产| 香蕉精品亚洲二区在线观看| 无码国模大尺度视频在线观看| 精品一品国产午夜福利视频| 蜜桃视频在线观看免费视频网站www| 4hu四虎永久在线观看| 成人午夜看黄在线尤物成人|