在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-HIST1H1E (T17) Antibody

  • 中文名稱:
    磷酸化-HIST1H1E (T17)兔多克隆抗體
  • 貨號:
    CSB-PA010380OA17phHU
  • 規格:
    ¥660
  • 圖片:
    • Western Blot
      Detected samples: Jurkat whole cell lysate, Hela whole cell lysate; Untreated (-) or treated (+) with Calyculin A and EGF
      All lanes: HIST1H1E antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 22 kDa
      Observed band size: 22 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA010380OA17phHU at 1:2.5, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HIST1H1E Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HIST1H1E
  • 別名:
    H1 histone family member 4 antibody; H1.4 antibody; H14_HUMAN antibody; H1E antibody; H1F4 antibody; Hist1h1e antibody; Histone 1 H1e antibody; Histone cluster 1 H1e antibody; Histone H1 antibody; Histone H1.4 antibody; Histone H1B antibody; MGC116819 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence around site of Phospho-Thr (17) derived from Human Histone H1.4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:1-1:10
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
  • 基因功能參考文獻:
    1. Results show that histones H1.2 and H1.4 were observed in MDA-MB-231 metastatic breast cancer cells. The phosphorylation at S173 of histone H1.2 and S172, S187, T18, T146, and T154 of H1.4 significantly increases during M phase suggesting that these events are cell cycle-dependent. PMID: 26209608
    2. This study identified and confirmed HIST1H1E protein changes within the postsynaptic density in schizophrenia. PMID: 25048004
    3. the N-terminal domain of H1 is an important determinant of affinity and specificity of H1-chromatin interactions. PMID: 22425985
    4. PKA-mediated H1.4S35 phosphorylation dissociates H1.4 from mitotic chromatin but also suggest that this phosphorylation is necessary for specific mitotic functions. PMID: 21852232
    5. Allele-specific underacetylation of histone H4 downstream from promoter is associated with X-inactivation in human cells. PMID: 12498347
    6. the lysine residue adjacent to the phosphorylation site found on the serine residue on the H1.4 peptide KARKSAGAAKR was also shown to be methylated, raising the question of whether the hypothesized "methyl/phos" switch could be extended to linker histones PMID: 15595731
    7. Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins PMID: 19144645

    顯示更多

    收起更多

  • 相關疾病:
    Rahman syndrome (RMNS)
  • 亞細胞定位:
    Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus.
  • 蛋白家族:
    Histone H1/H5 family
  • 數據庫鏈接:

    HGNC: 4718

    OMIM: 142220

    KEGG: hsa:3008

    STRING: 9606.ENSP00000307705

    UniGene: Hs.248133



主站蜘蛛池模板: 中国少妇偷人hd| 中文字幕卡二和卡三的视频| 久久精品人人槡人妻人人玩av | 拍国产乱人伦偷精品视频| 极品无码国模国产在线观看| 亚洲精品久久久久久久蜜桃臀| 老鲁夜夜老鲁| 色综合天天视频在线观看| 激情97综合亚洲色婷婷五| 国精产品一区一区三区免费视频 | 色午夜一av男人的天堂| 曰本极品少妇videossexhd | 天堂在/线中文在线资源 官网| 动漫精品中文无码卡通动漫| 1000部啪啪未满十八勿入| 亚洲一线二线三线写真| a狠狠久久蜜臀婷色中文网| 午夜无码国产理论在线| 人妻色综合网站| 国产中文欧美日韩在线| 妺妺跟我一起洗澡没忍住| 亚洲欧洲综合有码无码| 青青草原综合久久大伊人精品| 少妇放荡的呻吟干柴烈火动漫 | 国产三区在线成人av| 国产激情综合在线看| 在线视频观看免费视频18| 国产精品久久久久久无码| 学生精品国产在线视频| 麻豆精品传媒一二三区艾秋| 久久久www成人免费无遮挡大片 | 亚洲风影视传媒有限公司辽宁 | 一本大道伊人av久久综合| 成人精品一区二区三区中文字幕| 国产高清-国产av| 国色天香社区视频| 久久久精品中文字幕麻豆发布| 饥渴少妇做私密保健视频| 久久婷婷是五月综合色| 午夜熟女插插xx免费视频| 99热99这里只有高清国产|